Multicenter Prospective Study of Ulcerated Hemangiomas

Sarah L. Chamlin, Anita N. Haggstrom, Beth A. Drolet, Eulalia Baselga, Ilona J. Frieden, Maria C. Garzon, Kimberly A. Horii, Anne W. Lucky, Denise W. Metry, Brandon Newell, Amy Jo Nopper, Anthony J. Mancini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

153 Scopus citations


Objective: To identify clinical features of infants with ulcerated infantile hemangiomas. Study design: Cross-sectional analysis was conducted within a prospective cohort study of children with infantile hemangiomas. Children younger than 12 years of age were recruited. Demographic and prenatal/perinatal information was collected. Hemangioma size, location, subtype, course, complications, and treatments were recorded. Results: One thousand ninety-six patients were enrolled, and 173 (15.8%) patients experienced ulceration. Ulceration occurred in 192 (9.8%) of 1096 total hemangiomas. Hemangiomas with ulcerations were more likely large, mixed clinical type, segmental morphologic type, and located on the lower lip, neck, or anogenital region. Ulceration occurred at a median age of 4 months, most often during the proliferative phase. Children with ulcerated hemangiomas were more likely to present to a pediatric dermatologist at a younger age and to require treatment. Bleeding occurred in 41% of ulcerated lesions but was rarely of clinical significance. Infection occurred in 16%. Conclusions: Ulceration occurs in nearly 16% of patients with infantile hemangiomas, most often by 4 months of age, during the proliferative phase. Location, size, and clinical and morphologic type are associated with an increased risk for development of ulceration.

Original languageEnglish (US)
Pages (from-to)684-689.e1
JournalJournal of Pediatrics
Issue number6
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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