Multichannel optrodes for photonic stimulation

Yingyue Xu, Nan Xia, Michelle Lim, Xiaodong Tan, Minh Ha Tran, Erin Boulger, Fei Peng, Hunter Young, Christoph Rau, Alexander Rack, Claus Peter Richter*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

An emerging method in the field of neural stimulation is the use of photons to activate neurons. The possible advantage of optical stimulation over electrical is attributable to its spatially selective activation of small neuron populations, which is promising in generating superior spatial resolution in neural interfaces. Two principal methods are explored for cochlear prostheses: Direct stimulation of nerves with infrared light and optogenetics. This paper discusses basic requirements for developing a light delivery system (LDS) for the cochlea and provides examples for building such devices. The proposed device relies on small optical sources, which are assembled in an array to be inserted into the cochlea. The mechanical properties, the biocompatibility, and the efficacy of optrodes have been tested in animal models. The force required to insert optrodes into a model of the human scala tympani was comparable to insertion forces obtained for contemporary cochlear implant electrodes. Side-emitting diodes are powerful enough to evoke auditory responses in Guinea pigs. Chronic implantation of the LDS did not elevate auditory brainstem responses over 26 weeks.

Original languageEnglish (US)
Article number045002
JournalNeurophotonics
Volume5
Issue number4
DOIs
StatePublished - Oct 1 2018

Keywords

  • cochlear implant
  • infrared neural stimulation
  • laser
  • light delivery system
  • optrode

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Xu, Y., Xia, N., Lim, M., Tan, X., Tran, M. H., Boulger, E., Peng, F., Young, H., Rau, C., Rack, A., & Richter, C. P. (2018). Multichannel optrodes for photonic stimulation. Neurophotonics, 5(4), [045002]. https://doi.org/10.1117/1.NPh.5.4.045002