Multidrug resistance due to P-glycoprotein

R. K. Burt, A. T. Fojo, S. S. Thorgeirsson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Clarification of P-glycoprotein as a mechanism of antineoplastic drug resistance and attempts to reverse this resistance with chemosensitizing agents offer an opportunity to tailor treatment to the susceptibility of each patient's tumor to chemotherapy. Determining the sensitivity and resistance of an organism before treatment is the standard of care in infectious disease. Oncology, on the other hand, has traditionally treated tumors according to histology. Understanding the basic mechanisms by which eukaryotic cells protect themselves from chemical insult may allow for a less morbid and more effectively targeted treatment of cancer. P-glycoprotein may become an important contribution to such an approach.

Original languageEnglish (US)
Pages (from-to)67-77
Number of pages11
JournalHospital Practice
Issue number4
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Medicine(all)


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