Multidrug-resistant gram-negative infections in transplant and oncology patients

Multidrug-resistant gram-negative infections cause significant mortality and morbidity in the transplant and oncology patient population. Prolonged hospitalization and prior exposure to broad-spectrum antibiotics are common risk factors. Prevention strategies include daily bathing with chlorhexidine gluconate and use of isolation precautions. Recent data suggest that carbapenems provide adequate empiric therapy for most patients. However, culture data should be closely monitored to avoid overuse of broad-spectrum therapy.