TY - JOUR
T1 - Multidrug-resistant gram-negative organisms and association with 1-year mortality, readmission, and length of stay in Veterans with spinal cord injuries and disorders
AU - Ramanathan, Swetha
AU - Fitzpatrick, Margaret A.
AU - Suda, Katie J.
AU - Burns, Stephen P.
AU - Jones, Makoto M.
AU - LaVela, Sherri L.
AU - Evans, Charlesnika T.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to International Spinal Cord Society.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Study design: Retrospective cohort study. Objectives: The goal of this study was to assess the impact of multidrug resistant gram-negative organisms (MDRGNOs) on outcomes in those with SCI/D. Setting: VA SCI System of Care, Department of Veterans Affairs, United States. Methods: Multidrug resistance (MDR) was defined as being non-susceptible to ≥1 antibiotic in ≥3 antibiotic classes. Multivariable cluster-adjusted regression models were fit to assess the association of MDRGNOs with 1-year mortality, 30-day readmission, and postculture length of stay (LOS) stratified by case setting patients. Only the first culture per patient during the study period was included. Results: A total of 8,681 individuals with SCI/D had a culture with gram-negative bacteria during the study period, of which 33.0% had a MDRGNO. Overall, 954 (10.9%) died within 1 year of culture date. Poisson regression showed that MDR was associated with 1-year mortality among outpatients (IRR: 1.28, 95% CI, 1.06–1.54) and long-term care patients (OR: 2.06, 95% CI, 1.28–3.31). MDR significantly impacted postculture LOS in inpatients, as evidenced by a 10% longer LOS in MDR vs. non-MDR (IRR: 1.10, 95% CI, 1.02–1.19). MDR was not associated with increased 30-day readmission. Conclusions: MDRGNOs are prevalent in SCI/D and MDR may result in poor outcomes. Further attention to prevention of infections, antibiotic stewardship, and management are warranted in this population.
AB - Study design: Retrospective cohort study. Objectives: The goal of this study was to assess the impact of multidrug resistant gram-negative organisms (MDRGNOs) on outcomes in those with SCI/D. Setting: VA SCI System of Care, Department of Veterans Affairs, United States. Methods: Multidrug resistance (MDR) was defined as being non-susceptible to ≥1 antibiotic in ≥3 antibiotic classes. Multivariable cluster-adjusted regression models were fit to assess the association of MDRGNOs with 1-year mortality, 30-day readmission, and postculture length of stay (LOS) stratified by case setting patients. Only the first culture per patient during the study period was included. Results: A total of 8,681 individuals with SCI/D had a culture with gram-negative bacteria during the study period, of which 33.0% had a MDRGNO. Overall, 954 (10.9%) died within 1 year of culture date. Poisson regression showed that MDR was associated with 1-year mortality among outpatients (IRR: 1.28, 95% CI, 1.06–1.54) and long-term care patients (OR: 2.06, 95% CI, 1.28–3.31). MDR significantly impacted postculture LOS in inpatients, as evidenced by a 10% longer LOS in MDR vs. non-MDR (IRR: 1.10, 95% CI, 1.02–1.19). MDR was not associated with increased 30-day readmission. Conclusions: MDRGNOs are prevalent in SCI/D and MDR may result in poor outcomes. Further attention to prevention of infections, antibiotic stewardship, and management are warranted in this population.
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U2 - 10.1038/s41393-019-0393-y
DO - 10.1038/s41393-019-0393-y
M3 - Article
C2 - 31827257
AN - SCOPUS:85076596264
SN - 1362-4393
VL - 58
SP - 596
EP - 608
JO - Spinal Cord
JF - Spinal Cord
IS - 5
ER -