Multifocal central nervous system damage caused by toluene abuse

Richard B. Lazar*, Sam U. Ho, Onur Melen, Amin N. Daghestani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter, and ocular dysmetria. All three patients tested had abnormal brainstem auditory evoked potentials, indicative of brainstem dysfunction. The patient with opsoclonus had CT evidence of brainstem, cerebellar, and cerebral cortical atrophy.

Original languageEnglish (US)
Pages (from-to)1337-1339
Number of pages3
Issue number10
StatePublished - Oct 1983

ASJC Scopus subject areas

  • Clinical Neurology


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