TY - PAT
T1 - MULTIFUNCTION NANOCONJUGATES FOR IMAGING APPLICATIONS AND TARGETED TREATMENT
AU - Paunesku, Tatjana
AU - Woloschak, Gayle
N1 - filingdate: 2009-3-13
issueddate: 2013-10-15
Status: published
attorneydocketnumber: 2006-153-02
PY - 2009/10/22
Y1 - 2009/10/22
N2 - Multifunction Nanoconjugates for Imaging Applications and Targeted Treatment
NU 2006-153, 2006-154, 2006-171, 2006-172, 2007-045, 2007-046
Inventors
Aiguo Wu
Tatjana Paunesku
Gayle E. Woloschak*
Abstract
Nanoparticles have a variety of medical uses. Northwestern scientists have developed multifunctional nanoparticles that can be used for diagnostic imaging and targeted therapy at the same time. They synthesized a group of novel core-shell nanoparticles coated with a variety of bio-molecules and conjugation chemistries. By tailoring the structure and composition of the nanoconjugates, the nanoparticles may be used individually or simultaneously for magnetic resonance imaging (MRI), computed tomography (CT) imaging, optical fluorescent imaging, and cell membrane targeting/penetration. Specific targeting and retention of the nanoparticles can be achieved by utilizing specific bio-active components: chemical therapeutic agents, nucleic acids, peptides and proteins each have different characteristics once added to nanoparticles. Transgenic experiments using a prostate cancer mouse model have already shown that both diagnostic MRI and efficiency of the chemotherapeutic drug doxorubicine are enhanced when the nanoparticles are utilized for imaging and drug delivery. The nanoparticles represent a multipurpose agent that offers a novel combination of diagnostic and therapeutic modalities, as well as improved applicability to current diagnostic methods with increased retention of contrast agent.
Applications
o Individual or simultaneous multiple diagnostic (CT, MRI and fluorescence imaging)
o Clinical applications (targeted treatment)
Advantages
o Flexible: easily tailored to be used individually or simultaneously
o Enhanced diagnostic images and drug delivery properties due to extended retention of the
imaging/pharmaceutical agent
IP Status
Patent applications have been filed.
Marketing Contact
Chao Zhang, PhD
Invention Associate
email: c-zhang3@northwestern.edu
phone: 847-491-4629
AB - Multifunction Nanoconjugates for Imaging Applications and Targeted Treatment
NU 2006-153, 2006-154, 2006-171, 2006-172, 2007-045, 2007-046
Inventors
Aiguo Wu
Tatjana Paunesku
Gayle E. Woloschak*
Abstract
Nanoparticles have a variety of medical uses. Northwestern scientists have developed multifunctional nanoparticles that can be used for diagnostic imaging and targeted therapy at the same time. They synthesized a group of novel core-shell nanoparticles coated with a variety of bio-molecules and conjugation chemistries. By tailoring the structure and composition of the nanoconjugates, the nanoparticles may be used individually or simultaneously for magnetic resonance imaging (MRI), computed tomography (CT) imaging, optical fluorescent imaging, and cell membrane targeting/penetration. Specific targeting and retention of the nanoparticles can be achieved by utilizing specific bio-active components: chemical therapeutic agents, nucleic acids, peptides and proteins each have different characteristics once added to nanoparticles. Transgenic experiments using a prostate cancer mouse model have already shown that both diagnostic MRI and efficiency of the chemotherapeutic drug doxorubicine are enhanced when the nanoparticles are utilized for imaging and drug delivery. The nanoparticles represent a multipurpose agent that offers a novel combination of diagnostic and therapeutic modalities, as well as improved applicability to current diagnostic methods with increased retention of contrast agent.
Applications
o Individual or simultaneous multiple diagnostic (CT, MRI and fluorescence imaging)
o Clinical applications (targeted treatment)
Advantages
o Flexible: easily tailored to be used individually or simultaneously
o Enhanced diagnostic images and drug delivery properties due to extended retention of the
imaging/pharmaceutical agent
IP Status
Patent applications have been filed.
Marketing Contact
Chao Zhang, PhD
Invention Associate
email: c-zhang3@northwestern.edu
phone: 847-491-4629
M3 - Patent
M1 - 8557290
ER -
