Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Min Jun Ko, Hyunsik Hong, Hyunjun Choi, Heemin Kang*, Dong Hyun Kim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Multifunctional magnetic nanoparticles (MNPs) exhibit unique properties, such as remote motion controllability, degradability, and diagnostic imaging, which are typically not shown in nonmagnetic nanomaterials. MNPs remotely controllable via magnetic fields offer advantages of high tissue penetrability and biocompatibility. In this review, recent advances of multifunctional MNPs exhibiting unique characteristic for therapeutic applications are summarized, which utilize the “dynamic” motion, iron ion degradation, or imaging-guided targeting of the MNPs under diverse magnetic field modes. The magnetic field-controlled MNP motion enables spatiotemporal and reversible in situ cell regulation and mechanosensitive molecule modulation or thermal energy generation. Furthermore, the iron-based MNPs can produce degraded ions and reactive oxygen species to enable targeted ferroptosis therapy with medical imaging-guided approaches. The state-of-the-art imaging-guided “dynamic” therapy using the MNPs that can provide in situ feedback at each therapeutic stage is highlighted. Potential hurdles in translating the magnetic dynamic imaging and therapy toward clinical practices are also discussed. The imaging capability of the MNPs during “dynamic” magneto-cell regulation enables noninvasive, safe, localized, and on-demand regulation for the state-of-the-art regenerative therapy, immunotherapy, and cancer treatment.

Original languageEnglish (US)
Article number2200053
JournalAdvanced NanoBiomed Research
Issue number11
StatePublished - Nov 2022


  • cancer therapy
  • dynamic therapy
  • imaging-guided therapy
  • magnetic nanoparticles
  • multifunctional nanoparticles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Engineering (miscellaneous)
  • Biomaterials


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