Multifunctional polymeric nanoparticles from diverse bioactive agents

Paul A. Bertin, Julianne M. Gibbs, Clifton Kwang Fu Shen, C. Shad Thaxton, William A. Russin, Chad A. Mirkin, SonBinh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

We present a rational approach for assembling diverse bioactive agents, such as DNA, proteins, and drug molecules, into core-shell multifunctional polymeric nanoparticles (PNPs) that can be internalized in human breast cancer cells. Using ring-opening metathesis polymerization (ROMP), block copolymers containing small-molecule drug segments (>50% w/w) and tosylated hexaethylene glycol segments were prepared and assembled into PNPs that allowed for the surface conjugation of single-stranded DNA sequences and/or tumor-targeting antibodies. The resulting antibody-functionalized particles were readily uptaken by breast cancer cells that overexpressed the corresponding antigens.

Original languageEnglish (US)
Pages (from-to)4168-4169
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number13
DOIs
StatePublished - Apr 5 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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