Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

Yoshiaki Hattori, Leo Falgout, Woosik Lee, Sung Young Jung, Emily Poon, Jung Woo Lee, Ilyoun Na, Amelia Geisler, Divya Sadhwani, Yihui Zhang, Yewang Su, Xiaoqi Wang, Zhuangjian Liu, Jing Xia, Huanyu Cheng, R. Chad Webb, Andrew P. Bonifas, Philip Won, Jae Woong Jeong, Kyung In JangYoung Min Song, Beatrice Nardone, Michael Nodzenski, Jonathan A. Fan, Yonggang Huang, Dennis P. West, Amy S. Paller, Murad Alam, Woon Hong Yeo, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin-like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of "epidermal electronics system" in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.

Original languageEnglish (US)
Pages (from-to)1597-1607
Number of pages11
JournalAdvanced Healthcare Materials
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Clinical study
  • Epidermal electronics
  • Multifunctional
  • Skin-like
  • Wound monitoring

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing'. Together they form a unique fingerprint.

  • Cite this

    Hattori, Y., Falgout, L., Lee, W., Jung, S. Y., Poon, E., Lee, J. W., Na, I., Geisler, A., Sadhwani, D., Zhang, Y., Su, Y., Wang, X., Liu, Z., Xia, J., Cheng, H., Webb, R. C., Bonifas, A. P., Won, P., Jeong, J. W., ... Rogers, J. A. (2014). Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing. Advanced Healthcare Materials, 3(10), 1597-1607. https://doi.org/10.1002/adhm.201400073