Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

Yoshiaki Hattori, Leo Falgout, Woosik Lee, Sung Young Jung, Emily Poon, Jung Woo Lee, Ilyoun Na, Amelia Geisler, Divya Sadhwani, Yihui Zhang, Yewang Su, Xiaoqi Wang, Zhuangjian Liu, Jing Xia, Huanyu Cheng, R. Chad Webb, Andrew P. Bonifas, Philip Won, Jae Woong Jeong, Kyung In Jang & 10 others Young Min Song, Beatrice Nardone, Michael Nodzenski, Jonathan A. Fan, Yonggang Huang, Dennis P. West, Amy S. Paller, Murad Alam, Woon Hong Yeo, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin-like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of "epidermal electronics system" in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.

Original languageEnglish (US)
Pages (from-to)1597-1607
Number of pages11
JournalAdvanced Healthcare Materials
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Wound Healing
Skin
Electronic equipment
Monitoring
Wounds and Injuries
Laminates
Disinfection
Sensors
Thermal Conductivity
Fractals
Touch
Thermal conductivity
Mechanics
Actuators
Skin Diseases
Hot Temperature
Equipment and Supplies
Temperature
Surgical Wound

Keywords

  • Clinical study
  • Epidermal electronics
  • Multifunctional
  • Skin-like
  • Wound monitoring

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Hattori, Yoshiaki ; Falgout, Leo ; Lee, Woosik ; Jung, Sung Young ; Poon, Emily ; Lee, Jung Woo ; Na, Ilyoun ; Geisler, Amelia ; Sadhwani, Divya ; Zhang, Yihui ; Su, Yewang ; Wang, Xiaoqi ; Liu, Zhuangjian ; Xia, Jing ; Cheng, Huanyu ; Webb, R. Chad ; Bonifas, Andrew P. ; Won, Philip ; Jeong, Jae Woong ; Jang, Kyung In ; Song, Young Min ; Nardone, Beatrice ; Nodzenski, Michael ; Fan, Jonathan A. ; Huang, Yonggang ; West, Dennis P. ; Paller, Amy S. ; Alam, Murad ; Yeo, Woon Hong ; Rogers, John A. / Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing. In: Advanced Healthcare Materials. 2014 ; Vol. 3, No. 10. pp. 1597-1607.
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abstract = "Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of {"}epidermal{"} electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin-like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of {"}epidermal electronics system{"} in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.",
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Hattori, Y, Falgout, L, Lee, W, Jung, SY, Poon, E, Lee, JW, Na, I, Geisler, A, Sadhwani, D, Zhang, Y, Su, Y, Wang, X, Liu, Z, Xia, J, Cheng, H, Webb, RC, Bonifas, AP, Won, P, Jeong, JW, Jang, KI, Song, YM, Nardone, B, Nodzenski, M, Fan, JA, Huang, Y, West, DP, Paller, AS, Alam, M, Yeo, WH & Rogers, JA 2014, 'Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing', Advanced Healthcare Materials, vol. 3, no. 10, pp. 1597-1607. https://doi.org/10.1002/adhm.201400073

Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing. / Hattori, Yoshiaki; Falgout, Leo; Lee, Woosik; Jung, Sung Young; Poon, Emily; Lee, Jung Woo; Na, Ilyoun; Geisler, Amelia; Sadhwani, Divya; Zhang, Yihui; Su, Yewang; Wang, Xiaoqi; Liu, Zhuangjian; Xia, Jing; Cheng, Huanyu; Webb, R. Chad; Bonifas, Andrew P.; Won, Philip; Jeong, Jae Woong; Jang, Kyung In; Song, Young Min; Nardone, Beatrice; Nodzenski, Michael; Fan, Jonathan A.; Huang, Yonggang; West, Dennis P.; Paller, Amy S.; Alam, Murad; Yeo, Woon Hong; Rogers, John A.

In: Advanced Healthcare Materials, Vol. 3, No. 10, 01.10.2014, p. 1597-1607.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing

AU - Hattori, Yoshiaki

AU - Falgout, Leo

AU - Lee, Woosik

AU - Jung, Sung Young

AU - Poon, Emily

AU - Lee, Jung Woo

AU - Na, Ilyoun

AU - Geisler, Amelia

AU - Sadhwani, Divya

AU - Zhang, Yihui

AU - Su, Yewang

AU - Wang, Xiaoqi

AU - Liu, Zhuangjian

AU - Xia, Jing

AU - Cheng, Huanyu

AU - Webb, R. Chad

AU - Bonifas, Andrew P.

AU - Won, Philip

AU - Jeong, Jae Woong

AU - Jang, Kyung In

AU - Song, Young Min

AU - Nardone, Beatrice

AU - Nodzenski, Michael

AU - Fan, Jonathan A.

AU - Huang, Yonggang

AU - West, Dennis P.

AU - Paller, Amy S.

AU - Alam, Murad

AU - Yeo, Woon Hong

AU - Rogers, John A.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin-like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of "epidermal electronics system" in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.

AB - Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of "epidermal" electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management. A skin-like, conformal electronics platform that can softly and reversibly laminate perilesionally at the sites of cutaneous wounds is presented to provide highly accurate, quantitative data of relevance to management of healing cascades in surgical site wounds. The use of this type of "epidermal electronics system" in a clinical setting with human subjects defines a set of procedures in sterilization, reuse, and quantitative measurement.

KW - Clinical study

KW - Epidermal electronics

KW - Multifunctional

KW - Skin-like

KW - Wound monitoring

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