Multifunctional wearable devices for diagnosis and therapy of movement disorders

Donghee Son, Jongha Lee, Shutao Qiao, Roozbeh Ghaffari, Jaemin Kim, Ji Eun Lee, Changyeong Song, Seok Joo Kim, Dong Jun Lee, Samuel Woojoo Jun, Shixuan Yang, Minjoon Park, Jiho Shin, Kyungsik Do, Mincheol Lee, Kwanghun Kang, Cheol Seong Hwang, Nanshu Lu, Taeghwan Hyeon, Dae Hyeong Kim*

*Corresponding author for this work

Research output: Contribution to journalArticle

791 Scopus citations

Abstract

Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalNature nanotechnology
Volume9
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Son, D., Lee, J., Qiao, S., Ghaffari, R., Kim, J., Lee, J. E., Song, C., Kim, S. J., Lee, D. J., Jun, S. W., Yang, S., Park, M., Shin, J., Do, K., Lee, M., Kang, K., Hwang, C. S., Lu, N., Hyeon, T., & Kim, D. H. (2014). Multifunctional wearable devices for diagnosis and therapy of movement disorders. Nature nanotechnology, 9(5), 397-404. https://doi.org/10.1038/nnano.2014.38