Multimeric Near IR-MR Contrast Agent for Multimodal in Vivo Imaging

Victoria S.R. Harrison, Christiane E. Carney, Keith William Macrenaris, Emily A. Waters, Thomas J Meade*

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal resolution. In particular, MR and optical imaging are an attractive combination that can be used to determine both molecular and anatomical information. Herein, we describe the synthesis and in vivo testing of two multimeric NIR-MR contrast agents that contain three Gd(III) chelates and an IR-783 dye moiety. One agent contains a PEG linker and the other a short alkyl linker. These agents label cells with extraordinary efficacy and can be detected in vivo using both imaging modalities. Biodistribution of the PEGylated agent shows observable fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)9108-9116
Number of pages9
JournalJournal of the American Chemical Society
Volume137
Issue number28
DOIs
StatePublished - Jul 22 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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