TY - JOUR
T1 - Multimeric Near IR-MR Contrast Agent for Multimodal in Vivo Imaging
AU - Harrison, Victoria S.R.
AU - Carney, Christiane E.
AU - MacRenaris, Keith W.
AU - Waters, Emily A.
AU - Meade, Thomas J.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/7/22
Y1 - 2015/7/22
N2 - Multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal resolution. In particular, MR and optical imaging are an attractive combination that can be used to determine both molecular and anatomical information. Herein, we describe the synthesis and in vivo testing of two multimeric NIR-MR contrast agents that contain three Gd(III) chelates and an IR-783 dye moiety. One agent contains a PEG linker and the other a short alkyl linker. These agents label cells with extraordinary efficacy and can be detected in vivo using both imaging modalities. Biodistribution of the PEGylated agent shows observable fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging. (Figure Presented).
AB - Multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal resolution. In particular, MR and optical imaging are an attractive combination that can be used to determine both molecular and anatomical information. Herein, we describe the synthesis and in vivo testing of two multimeric NIR-MR contrast agents that contain three Gd(III) chelates and an IR-783 dye moiety. One agent contains a PEG linker and the other a short alkyl linker. These agents label cells with extraordinary efficacy and can be detected in vivo using both imaging modalities. Biodistribution of the PEGylated agent shows observable fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging. (Figure Presented).
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U2 - 10.1021/jacs.5b04509
DO - 10.1021/jacs.5b04509
M3 - Article
C2 - 26083313
AN - SCOPUS:84937773192
VL - 137
SP - 9108
EP - 9116
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 28
ER -