Multimodal actions of neural stem cells in a mouse model of als: A meta-analysis

Yang D. Teng*, Susanna C. Benn, Steven N. Kalkanis, Jeremy M. Shefner, Renna C. Onario, Bin Cheng, Mahesh B. Lachyankar, Michael Marconi, Jianxue Li, Dou Yu, Inbo Han, Nicholas J. Maragakis, Jeronia Lládo, Kadir Erkmen, D. Eugene Redmond, Richard L. Sidman, Serge Przedborski, Jeffrey D. Rothstein, Robert H. Brown, Evan Y. Snyder

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its pathogenesis. Neural stem cells (NSCs) perform multiple actions within the nervous system to fulfill their functions of organogenesis and homeostasis. We test the hypothesis that transplanted, undifferentiated multipotent migratory NSCs may help to ameliorate an array of pathological mechanisms in the SOD1G93A transgenic mouse model of ALS. On the basis of a meta-analysis of 11 independent studies performed by a consortium of ALS investigators, we propose that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. The beneficial effects of transplanted NSCs seem to be mediated by a number of actions including their ability to produce trophic factors, preserve neuromuscular function, and reduce astrogliosis and inflammation. We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases.

Original languageEnglish (US)
Article number165ra164
JournalScience translational medicine
Issue number165
StatePublished - Dec 19 2012

ASJC Scopus subject areas

  • General Medicine


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