Multimodal Analgesia and Intraoperative Neuromonitoring

Kan Ma*, John F. Bebawy, Laura B. Hemmer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Intraoperative neuromonitoring has been a valuable tool for ensuring the functional integrity of vital neural structures by providing real-time feedback to the operative team during procedures where neurological structures are at risk. Commonly used intravenous and inhaled anesthetic drugs are known to affect waveform parameters measured with various intraoperative neuromonitoring modalities. While the concept of opioid-sparing multimodal analgesia has gained popularity in recent years, the impact of such a strategy on intraoperative neuromonitoring remains poorly characterized, in contrast to the more well-established concepts and literature regarding the effects of other hypnotic agents on neuromonitoring quality. The purpose of this focused review is to provide an overview of the clinical evidence pertaining to the pharmacological interaction of certain multimodal analgesics with routine intraoperative neuromonitoring modalities.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalJournal of Neurosurgical Anesthesiology
Issue number2
StatePublished - Apr 1 2023


  • evoked potential
  • intraoperative neuromonitoring
  • multimodal analgesia
  • neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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