Multimodal e-mental health treatment for depression: A feasibility trial

David C. Mohr, Jennifer Duffecy, Ling Jin, Evette J. Ludman, Adam Lewis, Mark Begale, Martin McCarthy

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Background: Internet interventions for depression have shown less than optimal adherence. This study describes the feasibility trial of a multimodal e-mental health intervention designed to enhance adherence and outcomes for depression. The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol. Objective: The objective of this feasibility trial was to examine if our Internet intervention plus manualized telephone support program would result in increased adherence rates and improvement in depression outcomes. Methods: This was a single arm feasibility trial of a 7-week intervention. Results: Of the 21 patients enrolled, 2 (9.5%) dropped out of treatment. Patients logged in 23.2 ± 12.2 times over the 7 weeks. Significant reductions in depression were found on all measures, including the Patient Health Questionnaire depression scale (PHQ-8) (Cohen's d = 1.96, P <.001), the Hamilton Rating Scale for Depression (d = 1.34, P <.001), and diagnosis of major depressive episode (P <.001). Conclusions: The attrition rate was far lower than seen either in Internet studies or trials of face-to-face interventions, and depression outcomes were substantial. These findings support the feasibility of providing a multimodal e-mental health treatment to patients with depression. Although it is premature to make any firm conclusions based on these data, they do support the initiation of a randomized controlled trial examining the independent and joint effects of Internet and telephone administered treatments for depression.

Original languageEnglish (US)
Pages (from-to)e48p.1-e48p.10
JournalJournal of medical Internet research
Issue number5
StatePublished - 2010


  • Depression
  • Feasibility
  • Internet
  • Telemedicine
  • Telephone

ASJC Scopus subject areas

  • Health Informatics


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