Multimodal epidermal devices for hydration monitoring

Siddharth Krishnan, Yunzhou Shi, R. Chad Webb, Yinji Ma, Philippe Bastien, Kaitlyn E. Crawford, Ao Wang, Xue Feng, Megan Manco, Jonas Kurniawan, Edward Tir, Yonggang Huang, Guive Balooch, Rafal M. Pielak, John A Rogers

Research output: Contribution to journalArticle

Abstract

Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skin-based pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, ‘skin-like’ formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.
Original languageEnglish (US)
Article number17014
JournalMicrosystems & Nanoengineering
Volume3
DOIs
StatePublished - 2017

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Equipment and Supplies
Skin
Hot Temperature
Thermal Conductivity
Electric Impedance
Pathology
Technology
Pressure
Temperature
In Vitro Techniques
Clinical Studies

Cite this

Krishnan, S., Shi, Y., Webb, R. C., Ma, Y., Bastien, P., Crawford, K. E., ... Rogers, J. A. (2017). Multimodal epidermal devices for hydration monitoring. Microsystems & Nanoengineering, 3, [17014]. https://doi.org/10.1038/micronano.2017.14
Krishnan, Siddharth ; Shi, Yunzhou ; Webb, R. Chad ; Ma, Yinji ; Bastien, Philippe ; Crawford, Kaitlyn E. ; Wang, Ao ; Feng, Xue ; Manco, Megan ; Kurniawan, Jonas ; Tir, Edward ; Huang, Yonggang ; Balooch, Guive ; Pielak, Rafal M. ; Rogers, John A. / Multimodal epidermal devices for hydration monitoring. In: Microsystems & Nanoengineering. 2017 ; Vol. 3.
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title = "Multimodal epidermal devices for hydration monitoring",
abstract = "Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skin-based pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, ‘skin-like’ formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.",
author = "Siddharth Krishnan and Yunzhou Shi and Webb, {R. Chad} and Yinji Ma and Philippe Bastien and Crawford, {Kaitlyn E.} and Ao Wang and Xue Feng and Megan Manco and Jonas Kurniawan and Edward Tir and Yonggang Huang and Guive Balooch and Pielak, {Rafal M.} and Rogers, {John A}",
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Krishnan, S, Shi, Y, Webb, RC, Ma, Y, Bastien, P, Crawford, KE, Wang, A, Feng, X, Manco, M, Kurniawan, J, Tir, E, Huang, Y, Balooch, G, Pielak, RM & Rogers, JA 2017, 'Multimodal epidermal devices for hydration monitoring', Microsystems & Nanoengineering, vol. 3, 17014. https://doi.org/10.1038/micronano.2017.14

Multimodal epidermal devices for hydration monitoring. / Krishnan, Siddharth; Shi, Yunzhou; Webb, R. Chad; Ma, Yinji; Bastien, Philippe; Crawford, Kaitlyn E.; Wang, Ao; Feng, Xue; Manco, Megan; Kurniawan, Jonas; Tir, Edward; Huang, Yonggang; Balooch, Guive; Pielak, Rafal M.; Rogers, John A.

In: Microsystems & Nanoengineering, Vol. 3, 17014, 2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multimodal epidermal devices for hydration monitoring

AU - Krishnan, Siddharth

AU - Shi, Yunzhou

AU - Webb, R. Chad

AU - Ma, Yinji

AU - Bastien, Philippe

AU - Crawford, Kaitlyn E.

AU - Wang, Ao

AU - Feng, Xue

AU - Manco, Megan

AU - Kurniawan, Jonas

AU - Tir, Edward

AU - Huang, Yonggang

AU - Balooch, Guive

AU - Pielak, Rafal M.

AU - Rogers, John A

PY - 2017

Y1 - 2017

N2 - Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skin-based pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, ‘skin-like’ formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

AB - Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skin-based pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, ‘skin-like’ formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

U2 - 10.1038/micronano.2017.14

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M3 - Article

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JO - Microsystems & Nanoengineering

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Krishnan S, Shi Y, Webb RC, Ma Y, Bastien P, Crawford KE et al. Multimodal epidermal devices for hydration monitoring. Microsystems & Nanoengineering. 2017;3. 17014. https://doi.org/10.1038/micronano.2017.14