Multimodal Imaging and Choroidal Volumetric Changes after Half-fluence PDT in Central Serous Chorioretinopathy

Marion R. Munk, Ronil Shah, Frankie Pappas, Dina Baddar, Brandon Wong, Lee Merrill Jampol, Amani A Fawzi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Purpose: The purpose of this study was to identify SD-OCT changes that correspond to leakage on fluorescein (FA) and indocyanine angiography (ICGA) and evaluate effect of half-fluence photodynamic therapy (PDT) on choroidal volume in chronic central serous choroidoretinopathy (CSC).Methods: Retrospective analysis of patients with chronic CSC who had undergone PDT. Baseline FA and ICGA images were overlaid on SD-OCT to identify OCT correlates of FA or ICGA hyperfluorescence. Choroidal volume was evaluated in a subgroup of eyes before and after PDT.Results: Twenty eyes were evaluated at baseline, of which seven eyes had choroidal volume evaluations at baseline and 3 months following PDT. SD-OCT changes corresponding to FA hyperfluorescence were subretinal fluid (73%), RPE microrip (50%), RPE double-layer sign (31%), RPE detachment (15%), and RPE thickening (8%). ICGA hyperfluoresence was correlated in 93% with hyperreflective spots in the superficial choroid. Choroidal volume decreased from 9.35 ± 1.99 to 8.52 ± 1.92 and 8.04 ± 1.7 mm3 (at 1 and 3 months post PDT, respectively, p ≤ 0.001).Conclusions: We identified specific OCT findings that correlate with FA and ICGA leakage sites. SD-OCT is a valuable tool to localize CSC lesions and may be useful to guide PDT treatment. Generalized choroidal volume decrease occurs following PDT and extends beyond PDT treatment site.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalCurrent Eye Research
Issue number1
StatePublished - Jan 2 2016


  • Central serous choroidoretinopathy
  • choroidal thickness
  • choroidal volume
  • fluorescein angiography
  • hyperfluorescence
  • indocyanine angiography
  • pigment epithelium detachment
  • SD-OCT

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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