TY - JOUR
T1 - Multimodal imaging of refractory Candida chorioretinitis progressing to endogenous endophthalmitis
AU - Lavine, Jeremy Arlin
AU - Mititelu, Mihai
N1 - Publisher Copyright:
© 2015, Lavine and Mititelu.
PY - 2015/12/8
Y1 - 2015/12/8
N2 - Background: Endogenous fungal endophthalmitis is a serious vision-threatening condition that occurs in immunosuppressed patients with candidemia. Findings: We report a complicated case of Candida albicans chorioretinitis that progressed to endophthalmitis. The patient required intravitreal and systemic anti-fungal medications with pars plana vitrectomy for successful treatment. Multimodal imaging using fundus photography, fluorescein angiography, spectral domain optical coherence tomography, and fundus autofluorescence was obtained throughout treatment. These modalities localized the Candida infection in the choroid, penetrating Bruch’s membrane, the retinal pigment epithelium, and the retina to enter the vitreous cavity. This infectious route resulted in loss of the retinal pigment epithelium, photoreceptors, and outer retinal layers, with scar formation that resulted in vision loss and increased future risk of choroidal neovascular membranes. Conclusions: Multimodal imaging of C. albicans chorioretinitis allows for accurate diagnosis, assessment of response to therapy, and prognosis for visual recovery and future complications.
AB - Background: Endogenous fungal endophthalmitis is a serious vision-threatening condition that occurs in immunosuppressed patients with candidemia. Findings: We report a complicated case of Candida albicans chorioretinitis that progressed to endophthalmitis. The patient required intravitreal and systemic anti-fungal medications with pars plana vitrectomy for successful treatment. Multimodal imaging using fundus photography, fluorescein angiography, spectral domain optical coherence tomography, and fundus autofluorescence was obtained throughout treatment. These modalities localized the Candida infection in the choroid, penetrating Bruch’s membrane, the retinal pigment epithelium, and the retina to enter the vitreous cavity. This infectious route resulted in loss of the retinal pigment epithelium, photoreceptors, and outer retinal layers, with scar formation that resulted in vision loss and increased future risk of choroidal neovascular membranes. Conclusions: Multimodal imaging of C. albicans chorioretinitis allows for accurate diagnosis, assessment of response to therapy, and prognosis for visual recovery and future complications.
KW - Candida albicans
KW - Chorioretinitis
KW - Endophthalmitis
KW - Fluorescein angiography
KW - Fundus autofluorescence
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=84938567448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938567448&partnerID=8YFLogxK
U2 - 10.1186/s12348-015-0054-z
DO - 10.1186/s12348-015-0054-z
M3 - Article
C2 - 26253239
AN - SCOPUS:84938567448
SN - 1869-5760
VL - 5
JO - Journal of Ophthalmic Inflammation and Infection
JF - Journal of Ophthalmic Inflammation and Infection
IS - 1
M1 - 24
ER -