Multimodal microscopy for comprehensive tissue characterizations

Shuliang Jiao*, Hao F. Zhang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


This chapter describes the integration of photoacoustic microscopy (PAM) with other optical microscopic imaging modalities to achieve simultaneous multimodal imaging. We first discuss solving the compatibility issue among PAM and other imaging modalities by introducing the laser-scanning optical-resolution PAM. We then discuss the integration of PAM with optical coherence tomography (OCT) and confocal microscopy for providing both optical absorption and optical scattering contrasts. We also discuss improving the lateral resolution of PAM with adaptive optics. Finally, as an important application, we discuss multimodal imaging of the retina.

Original languageEnglish (US)
Title of host publicationAdvanced Biophotonics
Subtitle of host publicationTissue Optical Sectioning
PublisherCRC Press
Number of pages31
ISBN (Electronic)9781439895825
ISBN (Print)9781439895818
StatePublished - Apr 19 2016


  • Absorption contrast
  • Adaptive optics
  • Autofluorescence imaging
  • Lipofuscin
  • Melanin
  • Multimodal imaging
  • Ophthalmic imaging
  • Optical coherence tomography
  • Photoacoustic imaging
  • Photoacoustic microscopy
  • Retinal blood vessels
  • Retinal imaging
  • Retinal pigment epithelium

ASJC Scopus subject areas

  • General Engineering
  • General Physics and Astronomy
  • General Biochemistry, Genetics and Molecular Biology


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