Multimodal pain management in total knee arthroplasty. a prospective randomized controlled trial.

Joseph D. Lamplot, Eric R. Wagner, David W. Manning

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


We analyze the effects of a multimodal analgesic regimen on postoperative pain, function, adverse effects and satisfaction compared to patient-controlled analgesia (PCA). Thirty-six patients undergoing TKA were randomized to receive either (1) periarticular injection before wound closure (30cc 0.5% bupivacaine, 10mg MSO4, 15mg ketorolac) and multimodal analgesics (oxycodone, tramadol, ketorolac; narcotics as needed) or (2) hydromorphone PCA. Preoperative and postoperative data were collected for VAS pain scores, time to physical therapy milestones, hospital stay length, patient satisfaction, narcotic consumption and medication-related adverse effects. The multimodal group had lower VAS scores, fewer adverse effects, lower narcotic usage, higher satisfaction scores and earlier times to physical therapy milestones. Multimodal pain management protocol decreases narcotic usage, improves pain scores, increases satisfaction and enhances early recovery.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalJournal of Arthroplasty
Issue number2
StatePublished - Feb 2014


  • Fast-track
  • Minimally invasive TKA
  • Multimodal
  • Pain management
  • Periarticular injection
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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