Multinucleation of transformed cells normalizes their spreading on the substratum and their cytoskeleton structure

A. D. Bershadsky*, V. I. Gelfand, J. M. Vasiliev

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Transformed mouse fibroblasts of L line and cells of their highly oncogenic TLSF subline are deficiently spread on the solid substratum, do not form focal contacts with it and do not contain microfilament bundles. Polykaryons were produced from these cells by polyethylene glycol-induced cell fusion or by cytochalasin B-induced block of cytokinesis. Multinuclear cells obtained by both methods were much better spread on the substrate than their mononuclear counterparts. Most of the polykaryons have numerous actin microfilament bundles and form focal contacts with substratum. Therefore, multinucleation of transformed fibroblasts results in their partial morphological normalization.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalCell Biology International Reports
Volume5
Issue number2
DOIs
StatePublished - Feb 1981

ASJC Scopus subject areas

  • Cell Biology

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