Multiparametric measurement of cerebral physiology using calibrated fMRI

Molly Bright, Paula L. Croal, Nicholas P. Blockley, Daniel P. Bulte*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO 2 ), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO 2 , many other physiological parameters of interest are often acquired along the way. This can significantly increase the value of the dataset, providing greater information that is clinically relevant, or detail that can disambiguate the cause of signal variations. This can also be somewhat of a double-edged sword: calibrated fMRI experiments combine multiple parameters into a physiological model that requires multiple steps, thereby providing more opportunity for error propagation and increasing the noise and error of the final derived values. As with all measurements, there is a trade-off between imaging time, spatial resolution, coverage, and accuracy. In this review, we provide a brief overview of the benefits and pitfalls of extracting multiparametric measurements of cerebral physiology through calibrated fMRI experiments.

Original languageEnglish (US)
Pages (from-to)128-144
Number of pages17
JournalNeuroimage
Volume187
DOIs
StatePublished - Feb 15 2019

Fingerprint

Magnetic Resonance Imaging
Noise
Oxygen
Datasets

Keywords

  • ASL
  • BOLD
  • CBF
  • Calibration
  • FMRI
  • Gas

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Bright, Molly ; Croal, Paula L. ; Blockley, Nicholas P. ; Bulte, Daniel P. / Multiparametric measurement of cerebral physiology using calibrated fMRI. In: Neuroimage. 2019 ; Vol. 187. pp. 128-144.
@article{1ad601d520684ae19848f1a977dcf207,
title = "Multiparametric measurement of cerebral physiology using calibrated fMRI",
abstract = "The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO 2 ), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO 2 , many other physiological parameters of interest are often acquired along the way. This can significantly increase the value of the dataset, providing greater information that is clinically relevant, or detail that can disambiguate the cause of signal variations. This can also be somewhat of a double-edged sword: calibrated fMRI experiments combine multiple parameters into a physiological model that requires multiple steps, thereby providing more opportunity for error propagation and increasing the noise and error of the final derived values. As with all measurements, there is a trade-off between imaging time, spatial resolution, coverage, and accuracy. In this review, we provide a brief overview of the benefits and pitfalls of extracting multiparametric measurements of cerebral physiology through calibrated fMRI experiments.",
keywords = "ASL, BOLD, CBF, Calibration, FMRI, Gas",
author = "Molly Bright and Croal, {Paula L.} and Blockley, {Nicholas P.} and Bulte, {Daniel P.}",
year = "2019",
month = "2",
day = "15",
doi = "10.1016/j.neuroimage.2017.12.049",
language = "English (US)",
volume = "187",
pages = "128--144",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

Multiparametric measurement of cerebral physiology using calibrated fMRI. / Bright, Molly; Croal, Paula L.; Blockley, Nicholas P.; Bulte, Daniel P.

In: Neuroimage, Vol. 187, 15.02.2019, p. 128-144.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multiparametric measurement of cerebral physiology using calibrated fMRI

AU - Bright, Molly

AU - Croal, Paula L.

AU - Blockley, Nicholas P.

AU - Bulte, Daniel P.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO 2 ), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO 2 , many other physiological parameters of interest are often acquired along the way. This can significantly increase the value of the dataset, providing greater information that is clinically relevant, or detail that can disambiguate the cause of signal variations. This can also be somewhat of a double-edged sword: calibrated fMRI experiments combine multiple parameters into a physiological model that requires multiple steps, thereby providing more opportunity for error propagation and increasing the noise and error of the final derived values. As with all measurements, there is a trade-off between imaging time, spatial resolution, coverage, and accuracy. In this review, we provide a brief overview of the benefits and pitfalls of extracting multiparametric measurements of cerebral physiology through calibrated fMRI experiments.

AB - The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO 2 ), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO 2 , many other physiological parameters of interest are often acquired along the way. This can significantly increase the value of the dataset, providing greater information that is clinically relevant, or detail that can disambiguate the cause of signal variations. This can also be somewhat of a double-edged sword: calibrated fMRI experiments combine multiple parameters into a physiological model that requires multiple steps, thereby providing more opportunity for error propagation and increasing the noise and error of the final derived values. As with all measurements, there is a trade-off between imaging time, spatial resolution, coverage, and accuracy. In this review, we provide a brief overview of the benefits and pitfalls of extracting multiparametric measurements of cerebral physiology through calibrated fMRI experiments.

KW - ASL

KW - BOLD

KW - CBF

KW - Calibration

KW - FMRI

KW - Gas

UR - http://www.scopus.com/inward/record.url?scp=85041361606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041361606&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2017.12.049

DO - 10.1016/j.neuroimage.2017.12.049

M3 - Article

VL - 187

SP - 128

EP - 144

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -