Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

S. John Liu, Stephen T. Magill, Harish N. Vasudevan, Stephanie Hilz, Javier E. Villanueva-Meyer, Sydney Lastella, Vikas Daggubati, Jordan Spatz, Abrar Choudhury, Brent A. Orr, Benjamin Demaree, Kyounghee Seo, Sean P. Ferris, Adam R. Abate, Nancy Ann Oberheim Bush, Andrew W. Bollen, Michael W. McDermott, Joseph F. Costello, David R. Raleigh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Tumor heterogeneity poses a barrier to cancer treatment. Liu et al. investigate radiographically distinct regions of an ependymoma tumor using transcriptomic, genetic, and epigenomic profiling and discover axes of gene expression programs that recapitulate normal brain development in addition to phylogenies that shed light on the tumorigenesis of ependymoma.

Original languageEnglish (US)
Pages (from-to)1300-1309.e5
JournalCell reports
Issue number5
StatePublished - Feb 4 2020
Externally publishedYes


  • C11orf95-RELA
  • DNA methylation
  • RNA sequencing
  • SETD2
  • brain tumor
  • cancer
  • ependymoma
  • epigenomics
  • exome sequencing
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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