Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

S. John Liu; Stephen T. Magill; Harish N. Vasudevan; Stephanie Hilz; Javier E. Villanueva-Meyer; Sydney Lastella; Vikas Daggubati; Jordan Spatz; Abrar Choudhury; Brent A. Orr; Benjamin Demaree; Kyounghee Seo; Sean P. Ferris; Adam R. Abate; Nancy Ann Oberheim Bush; Andrew W. Bollen; Michael W. McDermott; Joseph F. Costello; David R. Raleigh

doi:10.1016/j.celrep.2020.01.018

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

S. John Liu, Stephen T. Magill, Harish N. Vasudevan, Stephanie Hilz, Javier E. Villanueva-Meyer, Sydney Lastella, Vikas Daggubati, Jordan Spatz, Abrar Choudhury, Brent A. Orr, Benjamin Demaree, Kyounghee Seo, Sean P. Ferris, Adam R. Abate, Nancy Ann Oberheim Bush, Andrew W. Bollen, Michael W. McDermott, Joseph F. Costello, David R. Raleigh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Tumor heterogeneity poses a barrier to cancer treatment. Liu et al. investigate radiographically distinct regions of an ependymoma tumor using transcriptomic, genetic, and epigenomic profiling and discover axes of gene expression programs that recapitulate normal brain development in addition to phylogenies that shed light on the tumorigenesis of ependymoma.

Original language	English (US)
Pages (from-to)	1300-1309.e5
Journal	Cell reports
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.01.018
State	Published - Feb 4 2020
Externally published	Yes

Keywords

C11orf95-RELA
DNA methylation
RNA sequencing
SETD2
brain tumor
cancer
ependymoma
epigenomics
exome sequencing
magnetic resonance imaging

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.01.018

Cite this

Liu, S. J., Magill, S. T., Vasudevan, H. N., Hilz, S., Villanueva-Meyer, J. E., Lastella, S., Daggubati, V., Spatz, J., Choudhury, A., Orr, B. A., Demaree, B., Seo, K., Ferris, S. P., Abate, A. R., Oberheim Bush, N. A., Bollen, A. W., McDermott, M. W., Costello, J. F., & Raleigh, D. R. (2020). Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma. Cell reports, 30(5), 1300-1309.e5. https://doi.org/10.1016/j.celrep.2020.01.018

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title = "Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma",

abstract = "Tumor heterogeneity poses a barrier to cancer treatment. Liu et al. investigate radiographically distinct regions of an ependymoma tumor using transcriptomic, genetic, and epigenomic profiling and discover axes of gene expression programs that recapitulate normal brain development in addition to phylogenies that shed light on the tumorigenesis of ependymoma.",

keywords = "C11orf95-RELA, DNA methylation, RNA sequencing, SETD2, brain tumor, cancer, ependymoma, epigenomics, exome sequencing, magnetic resonance imaging",

author = "Liu, {S. John} and Magill, {Stephen T.} and Vasudevan, {Harish N.} and Stephanie Hilz and Villanueva-Meyer, {Javier E.} and Sydney Lastella and Vikas Daggubati and Jordan Spatz and Abrar Choudhury and Orr, {Brent A.} and Benjamin Demaree and Kyounghee Seo and Ferris, {Sean P.} and Abate, {Adam R.} and {Oberheim Bush}, {Nancy Ann} and Bollen, {Andrew W.} and McDermott, {Michael W.} and Costello, {Joseph F.} and Raleigh, {David R.}",

note = "Funding Information: We would like to thank and acknowledge David A. Solomon, MD, PhD for providing targeted DNA sequencing data and analysis using a Clinical-Laboratory-Improvement-Amendment-certified panel of 510 cancer-associated genes. D.R.R. is supported by NIH NCI award K08 CA212279-01 . S.T.M. is supported by NIH NCI award F32 CA213944-01 . Publisher Copyright: {\textcopyright} 2020",

year = "2020",

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doi = "10.1016/j.celrep.2020.01.018",

language = "English (US)",

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pages = "1300--1309.e5",

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Liu, SJ, Magill, ST, Vasudevan, HN, Hilz, S, Villanueva-Meyer, JE, Lastella, S, Daggubati, V, Spatz, J, Choudhury, A, Orr, BA, Demaree, B, Seo, K, Ferris, SP, Abate, AR, Oberheim Bush, NA, Bollen, AW, McDermott, MW, Costello, JF & Raleigh, DR 2020, 'Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma', Cell reports, vol. 30, no. 5, pp. 1300-1309.e5. https://doi.org/10.1016/j.celrep.2020.01.018

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AU - Liu, S. John

AU - Magill, Stephen T.

AU - Vasudevan, Harish N.

AU - Hilz, Stephanie

AU - Villanueva-Meyer, Javier E.

AU - Lastella, Sydney

AU - Daggubati, Vikas

AU - Spatz, Jordan

AU - Choudhury, Abrar

AU - Orr, Brent A.

AU - Demaree, Benjamin

AU - Seo, Kyounghee

AU - Ferris, Sean P.

AU - Abate, Adam R.

AU - Oberheim Bush, Nancy Ann

AU - Bollen, Andrew W.

AU - McDermott, Michael W.

AU - Costello, Joseph F.

AU - Raleigh, David R.

N1 - Funding Information: We would like to thank and acknowledge David A. Solomon, MD, PhD for providing targeted DNA sequencing data and analysis using a Clinical-Laboratory-Improvement-Amendment-certified panel of 510 cancer-associated genes. D.R.R. is supported by NIH NCI award K08 CA212279-01 . S.T.M. is supported by NIH NCI award F32 CA213944-01 . Publisher Copyright: © 2020

PY - 2020/2/4

Y1 - 2020/2/4

N2 - Tumor heterogeneity poses a barrier to cancer treatment. Liu et al. investigate radiographically distinct regions of an ependymoma tumor using transcriptomic, genetic, and epigenomic profiling and discover axes of gene expression programs that recapitulate normal brain development in addition to phylogenies that shed light on the tumorigenesis of ependymoma.

AB - Tumor heterogeneity poses a barrier to cancer treatment. Liu et al. investigate radiographically distinct regions of an ependymoma tumor using transcriptomic, genetic, and epigenomic profiling and discover axes of gene expression programs that recapitulate normal brain development in addition to phylogenies that shed light on the tumorigenesis of ependymoma.

KW - C11orf95-RELA

KW - DNA methylation

KW - RNA sequencing

KW - SETD2

KW - brain tumor

KW - cancer

KW - ependymoma

KW - epigenomics

KW - exome sequencing

KW - magnetic resonance imaging

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SN - 2211-1247

VL - 30

SP - 1300-1309.e5

JO - Cell Reports

JF - Cell Reports

IS - 5

ER -

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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