Multiple gene products are produced from a novel protein kinase transcription region

D. Martin Watterson*, Mark Collinge, Thomas J. Lukas, Linda J. Van Eldik, Konstantin G. Birukov, Olga V. Stepanova, Vladimir P. Shirinsky

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The nonmuscle/smooth muscle myosin light chain kinase (MLCK) and the kinase related protein (KRP) that lacks protein kinase activity are myosin II binding proteins encoded in the vertebrate genome by a true gene within a gene relationship. The genomic organization and expression result in the same amino acid sequence in different molecular contexts from two different sizes of mRNA. We report here the identification and characterization of a third size class of gene products. The protein appears to be a higher molecular weight form of MLCK with additional amino terminal tail sequence which might provide differential subcellular targeting characteristics.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalFEBS Letters
Volume373
Issue number3
DOIs
StatePublished - Oct 16 1995

Keywords

  • Amino acid sequence
  • Calmodulin
  • Gene expression
  • Myosin
  • Protein kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Martin Watterson, D., Collinge, M., Lukas, T. J., Van Eldik, L. J., Birukov, K. G., Stepanova, O. V., & Shirinsky, V. P. (1995). Multiple gene products are produced from a novel protein kinase transcription region. FEBS Letters, 373(3), 217-220. https://doi.org/10.1016/0014-5793(95)01048-J