Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression

Maria Estela Martinez-Escala, Sapna Modi Amin, Kimberly Anne Sable, Pedram Gerami, Joan Guitart*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. The immunosuppressive effect of MF infiltrate in conjunction with the systemic effect of treatments may play a specific role in the nevomelanogenesis of the patients herein described.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalPediatric dermatology
Volume36
Issue number2
DOIs
StatePublished - Mar 1 2019

Keywords

  • immune surveillance
  • immunosuppression
  • melanocytic nevi
  • mycosis fungoides
  • pediatric
  • senescence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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