Multiple Memory Deficits in Patients with Multiple Sclerosis: Exploring the Working Memory System

Irene Litvan, Jordan Grafman, Pere Vendrell, José M. Martinez, Carme Junqué, Josep M. Vendrell, J. Luis Barraquer Bordas

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Some patients with multiple sclerosis (MS) demonstrate impaired memory. A group of 16 patients with MS who were mildly to moderately affected (Kurtzke Expanded Disability Status Scale Score = 3.8) were studied, and they were compared with a matched control group on tests of “working memory.” The working memory system was explored by evaluating the amount of information that can temporarily be held in a buffer system during encoding. Results indicated that patients with MS have difficulty in processing information at the level of a hypothesized articulatory loop in working memory. This deficit was correlated with their retrieval of verbal information from long-term memory, as well as how accurately they processed verbal information presented at a rapid rate. There was no significant relationship between ratings of MS severity or number of plaques visualized on magnetic resonance imaging scans and the degree of working memory deficit.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalArchives of Neurology
Volume45
Issue number6
DOIs
StatePublished - Jun 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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