Multiple neuromuscular abnormalities in a paranoid schizophrenic

J. Ross-Stanton; S. Schlessinger; H. Y. Meltzer

doi:10.1016/0165-1781(80)90047-5

Multiple neuromuscular abnormalities in a paranoid schizophrenic

J. Ross-Stanton, S. Schlessinger, H. Y. Meltzer^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the entire range of morphologic abnormalities. In addition to the morphologic abnormalities of skeletal muscle fibers, we also noted increases branching of subterminal motor nerves with enlarged endplates and chronic elevations of serum creatine phosphokinase activity. Despite this, the patient had minimal clinical evidence of neuromuscular dysfunction. The variety of types of neuromuscular dysfunctions found in this patient suggests their etiology may be related.

Original language	English (US)
Pages (from-to)	53-67
Number of pages	15
Journal	Psychiatry Research
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(80)90047-5
State	Published - 1980

Funding

Acknowledgments . This study was supported by grants USPHS MI-I-18,396, MH-16,127, and MH-30,938 and by the Department of Mental Health, State of Illinois . Dr . Meltzer is recipient of USPHS RCSA MH-47,808 .

Keywords

Schizophrenia
creatine phosphokinase (CPK)
skeletal muscle
subterminal neurons

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(80)90047-5

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title = "Multiple neuromuscular abnormalities in a paranoid schizophrenic",

abstract = "A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the entire range of morphologic abnormalities. In addition to the morphologic abnormalities of skeletal muscle fibers, we also noted increases branching of subterminal motor nerves with enlarged endplates and chronic elevations of serum creatine phosphokinase activity. Despite this, the patient had minimal clinical evidence of neuromuscular dysfunction. The variety of types of neuromuscular dysfunctions found in this patient suggests their etiology may be related.",

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N2 - A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the entire range of morphologic abnormalities. In addition to the morphologic abnormalities of skeletal muscle fibers, we also noted increases branching of subterminal motor nerves with enlarged endplates and chronic elevations of serum creatine phosphokinase activity. Despite this, the patient had minimal clinical evidence of neuromuscular dysfunction. The variety of types of neuromuscular dysfunctions found in this patient suggests their etiology may be related.

AB - A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the entire range of morphologic abnormalities. In addition to the morphologic abnormalities of skeletal muscle fibers, we also noted increases branching of subterminal motor nerves with enlarged endplates and chronic elevations of serum creatine phosphokinase activity. Despite this, the patient had minimal clinical evidence of neuromuscular dysfunction. The variety of types of neuromuscular dysfunctions found in this patient suggests their etiology may be related.

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Multiple neuromuscular abnormalities in a paranoid schizophrenic

Abstract

Funding

Keywords

ASJC Scopus subject areas

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