Multiple perceptible signals from a single olfactory glomerulus

Matthew Smear, Admir Resulaj, Jingji Zhang, Thomas C Bozza, Dmitry Rinberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Glomeruli are functional units in the olfactory system. The mouse olfactory bulb contains roughly 2,000 glomeruli, each receiving inputs from olfactory sensory neurons (OSNs) that express a specific odorant receptor gene. Odors typically activate many glomeruli in complex combinatorial patterns and it is unknown which features of neuronal activity in individual glomeruli contribute to odor perception. To address this, we used optogenetics to selectively activate single, genetically identified glomeruli in behaving mice. We found that mice could perceive the stimulation of a single glomerulus. Single-glomerulus stimulation was also detected on an intense odor background. In addition, different input intensities and the timing of input relative to sniffing were discriminated through one glomerulus. Our data suggest that each glomerulus can transmit odor information using identity, intensity and temporal coding cues. These multiple modes of information transmission may enable the olfactory system to efficiently identify and localize odor sources.

Original languageEnglish (US)
Pages (from-to)1687-1691
Number of pages5
JournalNature Neuroscience
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Multiple perceptible signals from a single olfactory glomerulus'. Together they form a unique fingerprint.

Cite this