TY - JOUR
T1 - Multiple scattering model for the penetration depth of low-coherence enhanced backscattering
AU - Turzhitsky, Vladimir
AU - Mutyal, Nikhil N.
AU - Radosevich, Andrew J.
AU - Backman, Vadim
N1 - Funding Information:
This work was supported by the National Institute of Health through Grant Nos. R01CA128641 and R01 EB003682.
PY - 2011/9
Y1 - 2011/9
N2 - Low-coherence enhanced backscattering (LEBS) is a depth-selective self-interference phenomenon that originates from light traveling time-reversed paths in a scattering medium. The depth selectivity of LEBS and its sensitivity to optical properties of the scattering medium has made it a promising technique for probing the structure of biological tissue with applications to disease diagnosis and, in particular, precancerous conditions. The ability to accurately predict the penetration depth of the LEBS signal is important in targeting an optimal tissue depth for detecting precancerous cells. This prediction is further complicated by the variation in optical properties of different tissue types. In this paper, the effects of the reduced scattering coefficient (μ s'), the phase function and the instrument spatial coherence length (L sc) on the LEBS penetration depth are quantified. It is determined that the LEBS penetration depth is primarily dependent on L sc, μ s', and the anisotropy factor (g), but has minimal dependence on higher moments of the phase function. An empirical expression, having a similar form as the double scattering approximation for LEBS, is found to accurately predict the average penetration depth in the multiple scattering regime. The expression is shown to be accurate for a broad range of experimentally relevant optical properties and spatial coherence lengths.
AB - Low-coherence enhanced backscattering (LEBS) is a depth-selective self-interference phenomenon that originates from light traveling time-reversed paths in a scattering medium. The depth selectivity of LEBS and its sensitivity to optical properties of the scattering medium has made it a promising technique for probing the structure of biological tissue with applications to disease diagnosis and, in particular, precancerous conditions. The ability to accurately predict the penetration depth of the LEBS signal is important in targeting an optimal tissue depth for detecting precancerous cells. This prediction is further complicated by the variation in optical properties of different tissue types. In this paper, the effects of the reduced scattering coefficient (μ s'), the phase function and the instrument spatial coherence length (L sc) on the LEBS penetration depth are quantified. It is determined that the LEBS penetration depth is primarily dependent on L sc, μ s', and the anisotropy factor (g), but has minimal dependence on higher moments of the phase function. An empirical expression, having a similar form as the double scattering approximation for LEBS, is found to accurately predict the average penetration depth in the multiple scattering regime. The expression is shown to be accurate for a broad range of experimentally relevant optical properties and spatial coherence lengths.
KW - backscattering
KW - coherence
KW - optical properties
KW - spectroscopy
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U2 - 10.1117/1.3625402
DO - 10.1117/1.3625402
M3 - Article
C2 - 21950941
AN - SCOPUS:80052529254
VL - 16
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 9
M1 - 097006
ER -