Multiple sclerosis: Empirical literature for the clinical health psychologist

David C. Mohr*, Darcy Cox

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


This article reviews the empirical literature related to clinical health psychology in multiple sclerosis (MS). MS is a disease in which the immune system attacks the central nervous system. As such, the interactions between medical and psychological variables are complex, and potentially of considerable importance to patients. Common neuropsychological and psychological problems associated with MS and their etiologies are reviewed. The effects of stress and depression on MS exacerbation are discussed, including clinical, immune, endocrine, and neuroimaging findings. The types of coping common in MS and their effects on adjustment are discussed. The empirical literature on psychological and neuropsychological intervention is reviewed. The small literature on caregiving in MS is also summarized.

Original languageEnglish (US)
Pages (from-to)479-499
Number of pages21
JournalJournal of Clinical Psychology
Issue number4
StatePublished - 2001


  • Central nervous system
  • Clinical health psychology
  • Depression
  • Multiple sclerosis
  • Stress

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Psychology

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