Abstract
Dose-response studies play an important role in many applications. Particularly in pharmaceutical drug development the assessment of a dose-related effect and the subsequent estimation of a target dose are of central importance. Clinical dose-finding studies are designed to investigate the effect of a given drug at several doses, possibly in comparison with a placebo group or an active control. Current clinical practice typically aims at two major goals when performing a dose-finding study (Ruberg, 1995a, 1995b; Bretz et al., 2008): First, one is interested in assessing an overall dose-response effect. The aim is thus to ensure that, by changing the dose, the response (efiicacy and/or safety) changes as well.
| Original language | English (US) |
|---|---|
| Title of host publication | Multiple Testing Problems in Pharmaceutical Statistics |
| Publisher | CRC Press |
| Pages | 99-130 |
| Number of pages | 32 |
| ISBN (Electronic) | 9781584889854 |
| ISBN (Print) | 9781584889847 |
| State | Published - Jan 1 2009 |
ASJC Scopus subject areas
- Mathematics(all)
- Medicine(all)
- Pharmacology, Toxicology and Pharmaceutics(all)