Multiple testing in dose-response problems

Frank Bretz, Ajit C Tamhane, José Pinheiro

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Dose-response studies play an important role in many applications. Particularly in pharmaceutical drug development the assessment of a dose-related effect and the subsequent estimation of a target dose are of central importance. Clinical dose-finding studies are designed to investigate the effect of a given drug at several doses, possibly in comparison with a placebo group or an active control. Current clinical practice typically aims at two major goals when performing a dose-finding study (Ruberg, 1995a, 1995b; Bretz et al., 2008): First, one is interested in assessing an overall dose-response effect. The aim is thus to ensure that, by changing the dose, the response (efiicacy and/or safety) changes as well.

Original languageEnglish (US)
Title of host publicationMultiple Testing Problems in Pharmaceutical Statistics
PublisherCRC Press
Number of pages32
ISBN (Electronic)9781584889854
ISBN (Print)9781584889847
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • General Mathematics
  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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