Multiple testing methodology

Alex Dmitrienko; Frank Bretz; Peter H. Westfall; James Troendle; Brian L. Wiens; Ajit C Tamhane; Jason C. Hsu

Multiple testing methodology

Alex Dmitrienko, Frank Bretz, Peter H. Westfall, James Troendle, Brian L. Wiens, Ajit C Tamhane, Jason C. Hsu

Industrial Engineering and Management Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

43 Scopus citations

Abstract

Multiplicity issues are encountered in a variety of pharmaceutical applications with multiple objectives. In a pre-clinical setting, the objectives can correspond to multiple genetic markers. In clinical applications, the objectives can be defined in terms of multiple dose levels, endpoints or subgroup analyses. Most common sources of multiplicity in clinical trials are listed below: Multiple dose-control comparisons are commonly included in dosefinding studies to evaluate efficacy and safety properties of a treatment compared to a control.

Original language	English (US)
Title of host publication	Multiple Testing Problems in Pharmaceutical Statistics
Publisher	CRC Press
Pages	35-98
Number of pages	64
ISBN (Electronic)	9781584889854
ISBN (Print)	9781584889847
State	Published - Jan 1 2009

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Medicine
General Mathematics

Cite this

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Multiple testing methodology

Abstract

ASJC Scopus subject areas

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