Multiple testing methodology

Alex Dmitrienko, Frank Bretz, Peter H. Westfall, James Troendle, Brian L. Wiens, Ajit C Tamhane, Jason C. Hsu

Research output: Chapter in Book/Report/Conference proceedingChapter

40 Scopus citations


Multiplicity issues are encountered in a variety of pharmaceutical applications with multiple objectives. In a pre-clinical setting, the objectives can correspond to multiple genetic markers. In clinical applications, the objectives can be defined in terms of multiple dose levels, endpoints or subgroup analyses. Most common sources of multiplicity in clinical trials are listed below: Multiple dose-control comparisons are commonly included in dosefinding studies to evaluate efficacy and safety properties of a treatment compared to a control.

Original languageEnglish (US)
Title of host publicationMultiple Testing Problems in Pharmaceutical Statistics
PublisherCRC Press
Number of pages64
ISBN (Electronic)9781584889854
ISBN (Print)9781584889847
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • General Mathematics
  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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