Multiple thiol-anchor capped DNA-gold nanoparticle conjugates

Zhi Li, Rongchao Jin, Chad A. Mirkin*, Robert L. Letsinger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

306 Scopus citations


We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.

Original languageEnglish (US)
Pages (from-to)1558-1562
Number of pages5
JournalNucleic acids research
Issue number7
StatePublished - Apr 1 2002

ASJC Scopus subject areas

  • Genetics

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