Multiple unrelated clonal abnormalities in host bone marrow cells after allogeneic stem cell transplantation

Partow Kebriaei, Jane N. Winter, Ginna G. Laport, Michelle M. Le Beau, Gordon Dewald, Richard A. Larson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A 22-year-old man with chronic myeloid leukemia (CML) received fractionated total body irradiation (TBI) (1440cGy) and etoposide (60mg/kg) followed by infusion of 10×106/kg CD34+ selected stem cells from his mother. Donor and recipient were 50% matched at the HLA-A and -B loci and 100% at HLA-DR. Mixed lymphocyte culture reaction was negative. Post-stem cell transplant (SCT) immunosuppression consisted of antithymocyte globulin, cyclosporine, and prednisone, and was discontinued after 7 months. The donor graft was rejected 2 years post-SCT. At 7 years post-SCT, he is clinically well with normal blood counts and no evidence of CML or myelodysplasia despite the presence over 6 years of multiple clones with balanced translocations and deletions in host bone marrow cells. The emergence of clonal hematopoiesis may provide insights into therapy-related leukemogenesis.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalLeukemia Research
Volume28
Issue number5
DOIs
StatePublished - May 2004

Keywords

  • Chronic myeloid leukemia
  • Cytogenetic abnormalities
  • Graft failure
  • Haplo-identical stem cell transplant
  • Therapy-related myelodysplasia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Multiple unrelated clonal abnormalities in host bone marrow cells after allogeneic stem cell transplantation'. Together they form a unique fingerprint.

Cite this