Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Ming San Ma; Nieske Brouwer; Evelyn Wesseling; Divya Raj; Johannes van der Want; Erik Boddeke; Veerakumar Balasubramaniyan; Sjef Copray

doi:10.1016/j.mcn.2015.02.002

Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Ming San Ma, Nieske Brouwer, Evelyn Wesseling, Divya Raj, Johannes van der Want, Erik Boddeke, Veerakumar Balasubramaniyan, Sjef Copray^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs.

Original language	English (US)
Pages (from-to)	21-30
Number of pages	10
Journal	Molecular and Cellular Neuroscience
Volume	65
DOIs	https://doi.org/10.1016/j.mcn.2015.02.002
State	Published - Mar 1 2015

Keywords

Hypothalamus
Nestin
Neural stem cells
Neurogenesis
Tanycytes
Third ventricle

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience
Cell Biology

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10.1016/j.mcn.2015.02.002

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title = "Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus",

abstract = "The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs.",

keywords = "Hypothalamus, Nestin, Neural stem cells, Neurogenesis, Tanycytes, Third ventricle",

author = "Ma, {Ming San} and Nieske Brouwer and Evelyn Wesseling and Divya Raj and {van der Want}, Johannes and Erik Boddeke and Veerakumar Balasubramaniyan and Sjef Copray",

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year = "2015",

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doi = "10.1016/j.mcn.2015.02.002",

language = "English (US)",

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AU - Ma, Ming San

AU - Brouwer, Nieske

AU - Wesseling, Evelyn

AU - Raj, Divya

AU - van der Want, Johannes

AU - Boddeke, Erik

AU - Balasubramaniyan, Veerakumar

AU - Copray, Sjef

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs.

AB - The present study describes for the first time the neural expression and distribution of UGS148, a protein encoded by the RIKEN cDNA63330403K07 gene that has been shown to be prominently and characteristically expressed in neural stem cells (NSCs). Based on its molecular structure, UGS148 is an intracellular protein expected to be involved in intracellular sorting, trafficking, exocytosis and membrane insertion of proteins. We demonstrate that UGS148 is highly expressed in embryonic NSCs as well as, albeit at low level, in the adult neurogenic niches, the subventricular zone and the hippocampal dentate gyrus. Interestingly, the highest expression level of UGS148 in the adult mouse brain was observed specifically in the neurogenic cells lining the third ventricle, the tanycytes. Our in vitro studies show the involvement of UGS148 in the regulation of the proliferation of NSCs.

KW - Hypothalamus

KW - Nestin

KW - Neural stem cells

KW - Neurogenesis

KW - Tanycytes

KW - Third ventricle

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JO - Molecular and Cellular Neuroscience

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Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Abstract

Keywords

ASJC Scopus subject areas

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