@article{7b1cde3f893740c1b1a25d4bce75171e,
title = "Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation",
abstract = "Innate lymphoid cells (ILCs) are well-characterized immune cells that play key roles in host defense and tissue homeostasis. Yet, how the three-dimensional (3D) genome organization underlies the development and functions of ILCs is unknown. Herein, we carried out an integrative analysis of the 3D genome structure, chromatin accessibility and gene expression in mature ILCs. Our results revealed that the local 3D configuration of the genome is rewired specifically at loci associated with ILC biology to promote their development and functional differentiation. Importantly, we demonstrated that the ontogenesis of ILC2s and the progression of allergic airway inflammation are determined by a unique local 3D configuration of the region containing the ILC-lineage-defining factor Id2, which is characterized by multiple interactions between the Id2 promoter and distal regulatory elements bound by the transcription factors GATA-3 and RORα, unveiling the mechanism whereby the Id2 expression is specifically controlled in group 2 ILCs.",
author = "Michieletto, {Micha{\"e}l F.} and Tello-Cajiao, {John J.} and Mowel, {Walter K.} and Aditi Chandra and Sora Yoon and Leonel Joannas and Clark, {Megan L.} and Jimenez, {Monica T.} and Wright, {Jasmine M.} and Patrick Lundgren and Adam Williams and Thaiss, {Christoph A.} and Golnaz Vahedi and Jorge Henao-Mejia",
note = "Funding Information: The work in this manuscript was supported by funds from CHOP and the NIH grant R01HL136572 (J. H-M.); the Burroughs Welcome Fund, the Chang Zuckerberg Initiative Award, and the NIH grant R01AI168240 (J. H-M. and G.V.); the PEW Charitable Trust (J. H-M. and J.J. T-C.); the NIH grants UC4 DK112217, U01DK11221702A1, R01HL145754, U01DK127768, U01DA052715 (G.V); and F31DK122677 (M.T.J.). Funding Information: The work in this manuscript was supported by funds from CHOP and the NIH grant R01HL136572 (J. H-M.); the Burroughs Welcome Fund, the Chang Zuckerberg Initiative Award, and the NIH grant R01AI168240 (J. H-M. and G.V.); the PEW Charitable Trust (J. H-M. and J.J. T-C.); the NIH grants UC4 DK112217, U01DK11221702A1, R01HL145754, U01DK127768, U01DA052715 (G.V); and F31DK122677 (M.T.J.). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
month = jan,
doi = "10.1038/s41590-022-01295-y",
language = "English (US)",
volume = "24",
pages = "42--54",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "1",
}