Multiscale framework for biomedical simulation from molecular dynamics to continuum mechanics

In biomedical engineering, computational mechanics has played an important role in understanding complex systems such as drug delivery platforms, biosensors and blood flow. In situations where a clinical test is either prohibitively difficult or required understaning, numerical experiments offer an effective way to gain important insight. For this reason computational methods have become essential tools for biomedical problems. In this paper, the multiscale framework for biomedical simulation is shown by applying various computational methods to several biomedical problems. To show the variety and breadth of the biomedical problems that can be addressed through computation, we describe several numerical methods that are capable of addressing the multiscale, multiphysics problems found in biological systems, and motivate each with sample applications. Specifically, molecular dynamics (MD), dissipate particle dynamics (DPD), elastic network model (ELM) and immersed molecular electrokinetic finite element method (IMEFEM) are introduced with state-of-the-art research topics in biotechnology.