Multiscale modeling and simulation for nanodiamond-based therapeutic delivery

Wing Kam Liu, Ashfaq Adnan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It has been dem onstrated from recent research that nanodiamond(ND)-enabled drug delivery as cancer therapeutics represents an important com ponent of optimized device functionality. The goal of the current research is to develop a multiscale modeling technique to underst and the fundamental mechanism of a ND-based cancer th erapeutic drug delivery system. The major components of the proposed device include nanodiamonds (ND), parylene buffer layer and doxorubicin (DOX) drugs, where DOX loaded self-assembled nanodi amonds are packed inside parylene capsule. The efficient functioning of the device is characterized by its ability to precisely detect targets (cancer cells) and then to release drugs at a controlled manner. The fundamental science issues concerni ng the development of the ND-based device includes (a) aprecise identification of the equilibrium structure, surface electrostatics and self assembled morphology of nanodi amonds, (b) underst anding of the drug/biomarker adsorption and desorpt ion process to and from NDs, (c) rate of drug release t hrough the parylene buffers, and finally, (d) device performance under physiological condition.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
PublisherASME
Pages237-238
Number of pages2
ISBN (Print)9780791843925
DOIs
StatePublished - 2010
Event1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010 - Houston, TX, United States
Duration: Feb 7 2010Feb 10 2010

Publication series

NameProceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010

Other

Other1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010
CountryUnited States
CityHouston, TX
Period2/7/102/10/10

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

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