TY - GEN
T1 - Multiscale modeling and simulation for nanodiamond-based therapeutic delivery
AU - Liu, Wing Kam
AU - Adnan, Ashfaq
PY - 2010
Y1 - 2010
N2 - It has been dem onstrated from recent research that nanodiamond(ND)-enabled drug delivery as cancer therapeutics represents an important com ponent of optimized device functionality. The goal of the current research is to develop a multiscale modeling technique to underst and the fundamental mechanism of a ND-based cancer th erapeutic drug delivery system. The major components of the proposed device include nanodiamonds (ND), parylene buffer layer and doxorubicin (DOX) drugs, where DOX loaded self-assembled nanodi amonds are packed inside parylene capsule. The efficient functioning of the device is characterized by its ability to precisely detect targets (cancer cells) and then to release drugs at a controlled manner. The fundamental science issues concerni ng the development of the ND-based device includes (a) aprecise identification of the equilibrium structure, surface electrostatics and self assembled morphology of nanodi amonds, (b) underst anding of the drug/biomarker adsorption and desorpt ion process to and from NDs, (c) rate of drug release t hrough the parylene buffers, and finally, (d) device performance under physiological condition.
AB - It has been dem onstrated from recent research that nanodiamond(ND)-enabled drug delivery as cancer therapeutics represents an important com ponent of optimized device functionality. The goal of the current research is to develop a multiscale modeling technique to underst and the fundamental mechanism of a ND-based cancer th erapeutic drug delivery system. The major components of the proposed device include nanodiamonds (ND), parylene buffer layer and doxorubicin (DOX) drugs, where DOX loaded self-assembled nanodi amonds are packed inside parylene capsule. The efficient functioning of the device is characterized by its ability to precisely detect targets (cancer cells) and then to release drugs at a controlled manner. The fundamental science issues concerni ng the development of the ND-based device includes (a) aprecise identification of the equilibrium structure, surface electrostatics and self assembled morphology of nanodi amonds, (b) underst anding of the drug/biomarker adsorption and desorpt ion process to and from NDs, (c) rate of drug release t hrough the parylene buffers, and finally, (d) device performance under physiological condition.
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U2 - 10.1115/nemb2010-13273
DO - 10.1115/nemb2010-13273
M3 - Conference contribution
AN - SCOPUS:77955070724
SN - 9780791843925
T3 - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
SP - 237
EP - 238
BT - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
PB - ASME
T2 - 1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010
Y2 - 7 February 2010 through 10 February 2010
ER -