Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Andrew C. Hunt, James Brett Case, Young Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Hsien Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien Ying Hsiang, Tyler N. Starr, Inna Goreshnik, Lisa Kozodoy, Lauren Carter, Rashmi Ravichandran, Lydia B. Green, Wadim L. MatochkoChristy A. Thomson, Bastian Vögeli, Antje Krüger, Laura A. VanBlargan, Rita E. Chen, Baoling Ying, Adam L. Bailey, Natasha M. Kafai, Scott E. Boyken, Ajasja Ljubetiè, Natasha Edman, George Ueda, Cameron M. Chow, Max Johnson, Amin Addetia, Mary Jane Navarro, Nuttada Panpradist, Michael Gale, Benjamin S. Freedman, Jesse D. Bloom, Hannele Ruohola-Baker, Sean P.J. Whelan, Lance Stewart, Michael S. Diamond*, David Veesler*, Michael C. Jewett*, David Baker*

*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Search results

  • SARS-CoV-2 spike in complex with AHB2-2GS-SB175 (local refinement of the RBD and AHB2)

    Hunt, A. C. (Contributor), Case, J. B. (Contributor), Park, Y.-J. (Contributor), Cao, L. (Contributor), Wu, K. (Contributor), Walls, A. C. (Contributor), Liu, Z. (Contributor), Bowen, J. E. (Contributor), Yeh, H.-W. (Contributor), Saini, S. (Contributor), Helms, L. (Contributor), Zhao, Y. T. (Contributor), Hsiang, T.-Y. (Contributor), Starr, T. N. (Contributor), Goreshnik, I. (Contributor), Kozodoy, L. (Contributor), Carter, L. (Contributor), Ravichandran, R. (Contributor), Green, L. B. (Contributor), Matochko, W. L. (Contributor), Thomson, C. A. (Contributor), Vögeli, B. (Contributor), Krüger, A. (Contributor), VanBlargan, L. A. (Contributor), Chen, R. E. (Contributor), Ying, B. (Contributor), Bailey, A. L. (Contributor), Kafai, N. M. (Contributor), Boyken, S. E. (Contributor), Ljubetiè, A. (Contributor), Edman, N. (Contributor), Ueda, G. (Contributor), Chow, C. M. (Contributor), Johnson, M. (Contributor), Addetia, A. (Contributor), Navarro, M.-J. (Contributor), Panpradist, N. (Contributor), Gale, M. (Contributor), Freedman, B. S. (Contributor), Bloom, J. D. (Contributor), Ruohola-Baker, H. (Contributor), Whelan, S. P. J. (Contributor), Stewart, L. (Contributor), Diamond, M. S. (Contributor), Veesler, D. (Contributor), Jewett, M. C. (Contributor) & Baker, D. (Contributor), Protein Data Bank (PDB), Jun 8 2022

    DOI: 10.2210/pdb7UHB/pdb, https://www.wwpdb.org/pdb?id=pdb_00007uhb

    Dataset

  • SARS-CoV-2 spike in complex with AHB2-2GS-SB175

    Hunt, A. C. (Contributor), Case, J. B. (Contributor), Park, Y.-J. (Contributor), Cao, L. (Contributor), Wu, K. (Contributor), Walls, A. C. (Contributor), Liu, Z. (Contributor), Bowen, J. E. (Contributor), Yeh, H.-W. (Contributor), Saini, S. (Contributor), Helms, L. (Contributor), Zhao, Y. T. (Contributor), Hsiang, T.-Y. (Contributor), Starr, T. N. (Contributor), Goreshnik, I. (Contributor), Kozodoy, L. (Contributor), Carter, L. (Contributor), Ravichandran, R. (Contributor), Green, L. B. (Contributor), Matochko, W. L. (Contributor), Thomson, C. A. (Contributor), Vögeli, B. (Contributor), Krüger, A. (Contributor), VanBlargan, L. A. (Contributor), Chen, R. E. (Contributor), Ying, B. (Contributor), Bailey, A. L. (Contributor), Kafai, N. M. (Contributor), Boyken, S. E. (Contributor), Ljubetiè, A. (Contributor), Edman, N. (Contributor), Ueda, G. (Contributor), Chow, C. M. (Contributor), Johnson, M. (Contributor), Addetia, A. (Contributor), Navarro, M.-J. (Contributor), Panpradist, N. (Contributor), Gale, M. (Contributor), Freedman, B. S. (Contributor), Bloom, J. D. (Contributor), Ruohola-Baker, H. (Contributor), Whelan, S. P. J. (Contributor), Stewart, L. (Contributor), Diamond, M. S. (Contributor), Veesler, D. (Contributor), Jewett, M. C. (Contributor) & Baker, D. (Contributor), Protein Data Bank (PDB), Jun 8 2022

    DOI: 10.2210/pdb7UHC/pdb, https://www.wwpdb.org/pdb?id=pdb_00007uhc

    Dataset