Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship to pleiomorphic gene products defining both immune-response genes and a restrictive requirement for cytotoxic T cells at H-2K

E. G. Neilson, S. M. Phillips

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Anti-tubular basement membrane (αTBM) disease-producing interstitial nephritis in mice is not dependent on the generation of αTBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cell in the pathogenesis of interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1075-1085
Number of pages11
JournalJournal of Experimental Medicine
Volume155
Issue number4
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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