Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine

William H. Hines, Richard A. Mann, Carolyn J. Kelly, Eric G. Neilson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The experiments presented in this report describe the biochemical and functional characteristics of a soluble Th cell factor (ThF) which can induce a nephritogenic effector T cell repertoire producing autoimmune interstitial nephritis. The ThF is Ag-specific, I-A-restricted, and comprises two chains noncovalently linked as a heterodimer. One chain at ~78,000 M(r) is related to the TCR/Id and expresses a framework determinant (14-30) common to Ag-binding factors, and the other chain at ~82,000 M(r) is I-A+. Together these chains can replace their parent cell by providing cognate help to precursor effector T lymphocytes in the presence of accessory cells, tubular Ag, and IL-2.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalJournal of Immunology
Volume144
Issue number1
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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