TY - JOUR
T1 - Murine interstitial nephritis
T2 - IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine
AU - Hines, William H.
AU - Mann, Richard A.
AU - Kelly, Carolyn J.
AU - Neilson, Eric G.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The experiments presented in this report describe the biochemical and functional characteristics of a soluble Th cell factor (ThF) which can induce a nephritogenic effector T cell repertoire producing autoimmune interstitial nephritis. The ThF is Ag-specific, I-A-restricted, and comprises two chains noncovalently linked as a heterodimer One chain at ∼78,000 Mr is related to the TCR/Id and expresses a framework determinant (14-30) common to Ag-binding factors, and the other chain at ∼82,000 Mr is I-A+. Together these chains can replace their parent cell by providing cognate help to precursor effector T lymphocytes in the presence of accessory cells, tubular Ag, and IL-2.
AB - The experiments presented in this report describe the biochemical and functional characteristics of a soluble Th cell factor (ThF) which can induce a nephritogenic effector T cell repertoire producing autoimmune interstitial nephritis. The ThF is Ag-specific, I-A-restricted, and comprises two chains noncovalently linked as a heterodimer One chain at ∼78,000 Mr is related to the TCR/Id and expresses a framework determinant (14-30) common to Ag-binding factors, and the other chain at ∼82,000 Mr is I-A+. Together these chains can replace their parent cell by providing cognate help to precursor effector T lymphocytes in the presence of accessory cells, tubular Ag, and IL-2.
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M3 - Article
C2 - 2136888
AN - SCOPUS:0025101486
SN - 0022-1767
VL - 144
SP - 75
EP - 83
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -