Phencyclidine (PCP) and ketamine were found to weakly inhibit rat skeletal muscle acetylcholinesterase (AChE) activity. PCP was a slightly more effective inhibitor of AChE than ketamine in vitro. PCP inhibited AChE activity in a noncompetitive manner which suggests the interaction of PCP at the secondary anionic site(s) of AChE whereas ketamine inhibited in a competitive manner, suggesting the interaction at the active site(s) of the enzyme. Both drugs also inhibited human muscle AChE activity in vitro. In vivo, both drugs stimulated rat skeletal muscle AChE activity whereas no effect was observed on rat brain AChE activity. When combined with restraints for 30 min following PCP and ketamine, the stimulation of AChE activity was greater than that produced by drug alone or restraint alone.
ASJC Scopus subject areas
- Developmental Neuroscience