Muscle extracellular matrix applies a transverse stress on fibers with axial strain

Lucas R. Smith, Lewis Gerace-Fowler, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

It is widely assumed that skeletal muscle contraction is isovolumic. This assumption has been verified at the single fiber and at the myofibril level. Model development and mechanical analyses often exploit this assumption when investigating skeletal muscle and evaluating muscle mechanical properties. This communication describes a method whereby individual muscle fibers and bundles of fibers, which include their constituent extracellular matrix (ECM), were tested to define the change in volume with axial strain. The results demonstrate that fibers are isovolumic, but bundles decrease in volume with strain. The loss of volume implicates a transverse force being applied to the fibers by the ECM. The nature and importance of this transverse force warrant further investigation.

Original languageEnglish (US)
Pages (from-to)1618-1620
Number of pages3
JournalJournal of Biomechanics
Volume44
Issue number8
DOIs
StatePublished - May 17 2011

Keywords

  • Extracellular matrix
  • Isovolumic
  • Muscle

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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