Muscle matters in kennedy's disease

Carlo Rinaldi; Laura C. Bott; Kenneth H. Fischbeck

doi:10.1016/j.neuron.2014.04.005

Muscle matters in kennedy's disease

Carlo Rinaldi, Laura C. Bott, Kenneth H. Fischbeck^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortesetal. (2014) in this issue of Neuron and Lieberman etal. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

Original language	English (US)
Pages (from-to)	251-253
Number of pages	3
Journal	Neuron
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2014.04.005
State	Published - Apr 16 2014

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2014.04.005

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title = "Muscle matters in kennedy's disease",

abstract = "Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortesetal. (2014) in this issue of Neuron and Lieberman etal. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.",

author = "Carlo Rinaldi and Bott, {Laura C.} and Fischbeck, {Kenneth H.}",

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T1 - Muscle matters in kennedy's disease

AU - Rinaldi, Carlo

AU - Bott, Laura C.

AU - Fischbeck, Kenneth H.

PY - 2014/4/16

Y1 - 2014/4/16

N2 - Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortesetal. (2014) in this issue of Neuron and Lieberman etal. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

AB - Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortesetal. (2014) in this issue of Neuron and Lieberman etal. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

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U2 - 10.1016/j.neuron.2014.04.005

DO - 10.1016/j.neuron.2014.04.005

M3 - Short survey

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SN - 0896-6273

VL - 82

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JO - Neuron

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Muscle matters in kennedy's disease

Abstract

ASJC Scopus subject areas

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