Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

Lu Han; Zhen ming Wang; Xiong Lu; Li Dong; Chao ming Xie; Ke feng Wang; Xiao lang Chen; Ding Yonghui; Lu tao Weng

doi:10.1016/j.colsurfb.2014.12.050

Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

Lu Han, Zhen ming Wang, Xiong Lu^*, Li Dong, Chao ming Xie, Ke feng Wang, Xiao lang Chen, Ding Yonghui, Lu tao Weng

^*Corresponding author for this work

MCC Center for Advanced Regenerative Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.

Original language	English (US)
Pages (from-to)	452-458
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	126
DOIs	https://doi.org/10.1016/j.colsurfb.2014.12.050
State	Published - Feb 1 2015

Funding

This project was financially supported by the 863 Program, NSFC ( 31070851 , 51202152 ), Sichuan Youth Science-Technology Foundation ( 2011JQ0010 ), and Construction Program for Innovative Research Team of University in Sichuan Province ( 14TD0050 ), the 2015 Doctoral Innovation Funds of Southwest Jiaotong University.

Keywords

BSA nanoparticles
Dexamethasone
Free-standing films
Oxidized alginate
Self-assembly
Vancomycin

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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Han, L., Wang, Z. M., Lu, X., Dong, L., Xie, C. M., Wang, K. F., Chen, X. L., Yonghui, D., & Weng, L. T. (2015). Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate. Colloids and Surfaces B: Biointerfaces, 126, 452-458. https://doi.org/10.1016/j.colsurfb.2014.12.050

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title = "Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate",

abstract = "This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.",

keywords = "BSA nanoparticles, Dexamethasone, Free-standing films, Oxidized alginate, Self-assembly, Vancomycin",

author = "Lu Han and Wang, {Zhen ming} and Xiong Lu and Li Dong and Xie, {Chao ming} and Wang, {Ke feng} and Chen, {Xiao lang} and Ding Yonghui and Weng, {Lu tao}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

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doi = "10.1016/j.colsurfb.2014.12.050",

language = "English (US)",

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Han, L, Wang, ZM, Lu, X, Dong, L, Xie, CM, Wang, KF, Chen, XL, Yonghui, D & Weng, LT 2015, 'Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate', Colloids and Surfaces B: Biointerfaces, vol. 126, pp. 452-458. https://doi.org/10.1016/j.colsurfb.2014.12.050

TY - JOUR

T1 - Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

AU - Han, Lu

AU - Wang, Zhen ming

AU - Lu, Xiong

AU - Dong, Li

AU - Xie, Chao ming

AU - Wang, Ke feng

AU - Chen, Xiao lang

AU - Yonghui, Ding

AU - Weng, Lu tao

PY - 2015/2/1

Y1 - 2015/2/1

N2 - This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.

AB - This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.

KW - BSA nanoparticles

KW - Dexamethasone

KW - Free-standing films

KW - Oxidized alginate

KW - Self-assembly

KW - Vancomycin

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Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

Abstract

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Keywords

ASJC Scopus subject areas

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