Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate

Lu Han, Zhen ming Wang, Xiong Lu*, Li Dong, Chao ming Xie, Ke feng Wang, Xiao lang Chen, Ding Yonghui, Lu tao Weng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume126
DOIs
StatePublished - Feb 1 2015

Keywords

  • BSA nanoparticles
  • Dexamethasone
  • Free-standing films
  • Oxidized alginate
  • Self-assembly
  • Vancomycin

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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