Mussel-inspired electrospun smart magnetic nanofibers for hyperthermic chemotherapy

Amin Ghavaminejad, Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Reju George Thomas, Yong Yeon Jeong, Mohammad Vatankhah-Varnoosfaderani, Florian J. Stadler*, Chan Hee Park, Cheol Sang Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment. Drug-loaded magnetic nanofibers are designed for a synergistic anticancer treatment that combines hyperthermia treatment and chemotherapy. A mussel-inspired binding is used to incorporate iron oxide nanoparticles (IONPs) and the drug onto the nanofibers. The smart nanofibers are capable of pH-dependent drug delivery to cancer cells, and their IONPs enable multiple cycles of hyperthermia therapy with the application of an alternating magnetic field (AMF).

Original languageEnglish (US)
Pages (from-to)2867-2875
Number of pages9
JournalAdvanced Functional Materials
Volume25
Issue number19
DOIs
StatePublished - May 1 2015

Keywords

  • biomedical applications
  • drug delivery
  • electrospinning
  • magnetic materials
  • multifunctional materials
  • nanofibers
  • nanoparticles

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics

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