Abstract
A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment. Drug-loaded magnetic nanofibers are designed for a synergistic anticancer treatment that combines hyperthermia treatment and chemotherapy. A mussel-inspired binding is used to incorporate iron oxide nanoparticles (IONPs) and the drug onto the nanofibers. The smart nanofibers are capable of pH-dependent drug delivery to cancer cells, and their IONPs enable multiple cycles of hyperthermia therapy with the application of an alternating magnetic field (AMF).
Original language | English (US) |
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Pages (from-to) | 2867-2875 |
Number of pages | 9 |
Journal | Advanced Functional Materials |
Volume | 25 |
Issue number | 19 |
DOIs | |
State | Published - May 1 2015 |
Keywords
- biomedical applications
- drug delivery
- electrospinning
- magnetic materials
- multifunctional materials
- nanofibers
- nanoparticles
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- Condensed Matter Physics