Mutagenesis studies of the H5 influenza hemagglutinin stem loop region

Aleksandar Antanasijevic; Arnab Basu; Terry L. Bowlin; Rama K. Mishra; Lijun Rong; Michael Caffrey

doi:10.1074/jbc.M114.572974

Mutagenesis studies of the H5 influenza hemagglutinin stem loop region

Aleksandar Antanasijevic, Arnab Basu, Terry L. Bowlin, Rama K. Mishra, Lijun Rong, Michael Caffrey^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: The stem loop region of influenza hemagglutinin plays a critical role in viral entry. Results: Novel site-directed mutants of the H5 hemagglutinin stem loop region were generated and characterized. Conclusion: The sensitivity of the stem loop region to mutation underscores its importance to function and attractiveness as a site for therapeutic intervention. Significance: Antibodies and drug-like molecules targeting the stem loop region of hemagglutinin are promising antivirals.

Original language	English (US)
Pages (from-to)	22237-22245
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.572974
State	Published - Aug 8 2014

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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abstract = "Background: The stem loop region of influenza hemagglutinin plays a critical role in viral entry. Results: Novel site-directed mutants of the H5 hemagglutinin stem loop region were generated and characterized. Conclusion: The sensitivity of the stem loop region to mutation underscores its importance to function and attractiveness as a site for therapeutic intervention. Significance: Antibodies and drug-like molecules targeting the stem loop region of hemagglutinin are promising antivirals.",

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AU - Basu, Arnab

AU - Bowlin, Terry L.

AU - Mishra, Rama K.

AU - Rong, Lijun

AU - Caffrey, Michael

PY - 2014/8/8

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AB - Background: The stem loop region of influenza hemagglutinin plays a critical role in viral entry. Results: Novel site-directed mutants of the H5 hemagglutinin stem loop region were generated and characterized. Conclusion: The sensitivity of the stem loop region to mutation underscores its importance to function and attractiveness as a site for therapeutic intervention. Significance: Antibodies and drug-like molecules targeting the stem loop region of hemagglutinin are promising antivirals.

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Mutagenesis studies of the H5 influenza hemagglutinin stem loop region

Abstract

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