Mutagenesis studies of the H5 influenza hemagglutinin stem loop region

Aleksandar Antanasijevic, Arnab Basu, Terry L. Bowlin, Rama K. Mishra, Lijun Rong, Michael Caffrey*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: The stem loop region of influenza hemagglutinin plays a critical role in viral entry. Results: Novel site-directed mutants of the H5 hemagglutinin stem loop region were generated and characterized. Conclusion: The sensitivity of the stem loop region to mutation underscores its importance to function and attractiveness as a site for therapeutic intervention. Significance: Antibodies and drug-like molecules targeting the stem loop region of hemagglutinin are promising antivirals.

Original languageEnglish (US)
Pages (from-to)22237-22245
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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