Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Sarah C. Nabinger; Sisi Chen; Rui Gao; Chonghua Yao; Michihiro Kobayashi; Sasidhar Vemula; Aidan C. Fahey; Christine Wang; Cecil Daniels; H. Scott Boswell; George E. Sandusky; Lindsey D. Mayo; Reuben Kapur; Yan Liu

doi:10.1038/s41375-019-0377-0

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Sarah C. Nabinger, Sisi Chen, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Sasidhar Vemula, Aidan C. Fahey, Christine Wang, Cecil Daniels, H. Scott Boswell, George E. Sandusky, Lindsey D. Mayo, Reuben Kapur, Yan Liu^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Letter › peer-review

14 Scopus citations

Original language	English (US)
Pages (from-to)	1535-1539
Number of pages	5
Journal	Leukemia
Volume	33
Issue number	6
DOIs	https://doi.org/10.1038/s41375-019-0377-0
State	Published - Jun 1 2019

Funding

Acknowledgements This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Bone Marrow Failure Research Program—Idea Development Award under Award No. W81XWH-18-1-0265 to YL. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. This work was also supported in part by two NIH R56 Awards (R56DK119524-01 and R56AG05250), a DoD Career Development Award W81XWH-13-1-0187, a Scholar Award from the St. Baldrick’s Foundation, an Elsa Pardee Foundation New Investigator Award, a Leukemia Research Foundation New Investigator Award, a Showalter Trust Fund New Investigator Award, an Alex Lemonade Stand Foundation grant, a Children’s Leukemia Research Association grant, and an American Cancer Society Institutional Research Grant to YL. SCN was supported by a NIH F32 Award 1F32CA203049-01.The authors would like to acknowledge the Flow Cytometry Core and In vivo Therapeutic Core Laboratories, which were sponsored, in part, by the NIDDK Cooperative Center of Excellence in Hematology (CCEH) grant U54 DK106846. This work was supported, in part, by a Project Development Team within the ICTSI NIH/NCRR Grant Number UL1TR001108. We would like to thank Dr. Yang Xu at USCD for providing the p53R248Wmice to the study.

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41375-019-0377-0

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title = "Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development",

author = "Nabinger, {Sarah C.} and Sisi Chen and Rui Gao and Chonghua Yao and Michihiro Kobayashi and Sasidhar Vemula and Fahey, {Aidan C.} and Christine Wang and Cecil Daniels and Boswell, {H. Scott} and Sandusky, {George E.} and Mayo, {Lindsey D.} and Reuben Kapur and Yan Liu",

note = "Funding Information: Acknowledgements This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Bone Marrow Failure Research Program—Idea Development Award under Award No. W81XWH-18-1-0265 to YL. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. This work was also supported in part by two NIH R56 Awards (R56DK119524-01 and R56AG05250), a DoD Career Development Award W81XWH-13-1-0187, a Scholar Award from the St. Baldrick{\textquoteright}s Foundation, an Elsa Pardee Foundation New Investigator Award, a Leukemia Research Foundation New Investigator Award, a Showalter Trust Fund New Investigator Award, an Alex Lemonade Stand Foundation grant, a Children{\textquoteright}s Leukemia Research Association grant, and an American Cancer Society Institutional Research Grant to YL. SCN was supported by a NIH F32 Award 1F32CA203049-01.The authors would like to acknowledge the Flow Cytometry Core and In vivo Therapeutic Core Laboratories, which were sponsored, in part, by the NIDDK Cooperative Center of Excellence in Hematology (CCEH) grant U54 DK106846. This work was supported, in part, by a Project Development Team within the ICTSI NIH/NCRR Grant Number UL1TR001108. We would like to thank Dr. Yang Xu at USCD for providing the p53R248Wmice to the study.",

year = "2019",

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doi = "10.1038/s41375-019-0377-0",

language = "English (US)",

volume = "33",

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T1 - Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

AU - Nabinger, Sarah C.

AU - Chen, Sisi

AU - Gao, Rui

AU - Yao, Chonghua

AU - Kobayashi, Michihiro

AU - Vemula, Sasidhar

AU - Fahey, Aidan C.

AU - Wang, Christine

AU - Daniels, Cecil

AU - Boswell, H. Scott

AU - Sandusky, George E.

AU - Mayo, Lindsey D.

AU - Kapur, Reuben

AU - Liu, Yan

N1 - Funding Information: Acknowledgements This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Bone Marrow Failure Research Program—Idea Development Award under Award No. W81XWH-18-1-0265 to YL. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. This work was also supported in part by two NIH R56 Awards (R56DK119524-01 and R56AG05250), a DoD Career Development Award W81XWH-13-1-0187, a Scholar Award from the St. Baldrick’s Foundation, an Elsa Pardee Foundation New Investigator Award, a Leukemia Research Foundation New Investigator Award, a Showalter Trust Fund New Investigator Award, an Alex Lemonade Stand Foundation grant, a Children’s Leukemia Research Association grant, and an American Cancer Society Institutional Research Grant to YL. SCN was supported by a NIH F32 Award 1F32CA203049-01.The authors would like to acknowledge the Flow Cytometry Core and In vivo Therapeutic Core Laboratories, which were sponsored, in part, by the NIDDK Cooperative Center of Excellence in Hematology (CCEH) grant U54 DK106846. This work was supported, in part, by a Project Development Team within the ICTSI NIH/NCRR Grant Number UL1TR001108. We would like to thank Dr. Yang Xu at USCD for providing the p53R248Wmice to the study.

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Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Funding

ASJC Scopus subject areas

UN SDGs

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