Mutation caused by human phagocytes

S. A. Weitzman, T. P. Stossel

Research output: Contribution to journalArticlepeer-review

205 Scopus citations

Abstract

Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

Original languageEnglish (US)
Pages (from-to)547-549
Number of pages3
JournalScience
Volume212
Issue number4494
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

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