Mutation caused by human phagocytes

S. A. Weitzman; T. P. Stossel

doi:10.1126/science.6259738

Mutation caused by human phagocytes

S. A. Weitzman, T. P. Stossel

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

Original language	English (US)
Pages (from-to)	547-549
Number of pages	3
Journal	Science
Volume	212
Issue number	4494
DOIs	https://doi.org/10.1126/science.6259738
State	Published - Jan 1 1981

ASJC Scopus subject areas

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abstract = "Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.",

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AB - Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

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