Mutation caused by human phagocytes

S. A. Weitzman; T. P. Stossel

doi:10.1126/science.6259738

Mutation caused by human phagocytes

S. A. Weitzman, T. P. Stossel

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

207 Scopus citations

Abstract

Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

Original language	English (US)
Pages (from-to)	547-549
Number of pages	3
Journal	Science
Volume	212
Issue number	4494
DOIs	https://doi.org/10.1126/science.6259738
State	Published - Jan 1 1981

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1126/science.6259738

Cite this

@article{1f9bb1cdbb234c1cbc6648ec4f3391c9,

title = "Mutation caused by human phagocytes",

abstract = "Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.",

author = "Weitzman, {S. A.} and Stossel, {T. P.}",

year = "1981",

month = jan,

day = "1",

doi = "10.1126/science.6259738",

language = "English (US)",

volume = "212",

pages = "547--549",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4494",

}

TY - JOUR

T1 - Mutation caused by human phagocytes

AU - Weitzman, S. A.

AU - Stossel, T. P.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

AB - Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

UR - http://www.scopus.com/inward/record.url?scp=0019794990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019794990&partnerID=8YFLogxK

U2 - 10.1126/science.6259738

DO - 10.1126/science.6259738

M3 - Article

C2 - 6259738

AN - SCOPUS:0019794990

VL - 212

SP - 547

EP - 549

JO - Science

JF - Science

SN - 0036-8075

IS - 4494

ER -

Mutation caused by human phagocytes

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this