Abstract
Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.
Original language | English (US) |
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Pages (from-to) | 547-549 |
Number of pages | 3 |
Journal | Science |
Volume | 212 |
Issue number | 4494 |
DOIs | |
State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- General