Mutations on the second chromosome affecting the drosophila Eye

Nicholas E. Baker*, Kevin Moses, Donna Nakahara, Michael C. Ellis, Richard W. Carthew, Gerald M. Rubin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

In the developing eye of Drosophila, cell interactions appear to be responsible for organising undifferentiated cells into unit eyes, or ommatidia. Extensive mutagenesis has been used to search for mutations affecting the development and differentiation of ommatidia. These mutations have been characterized using sections of adults and immunocytochemistry of imaginal discs. Fourteen loci on the second chromosome are described that affect the spacing of the preclusters, the differentiation of ommatidial cells, orientation of the ommatidia, or architecture of the adult retina, that cause retinal degeneration in larval or pupal eye discs, or that cause homeotic transformation of part of the head.

Original languageEnglish (US)
Pages (from-to)85-100
Number of pages16
JournalJournal of Neurogenetics
Volume8
Issue number2
DOIs
StatePublished - 1992

Funding

Drs. T. Schupbach and C. Sunkel for Drosophila stocks, Drs. S . Benzer, D. Bowtell and U. Gaul for antibodies. Drs. C. Montell and S. Cohen for testing alleles of nina C and DII respectively, Drs. J. Fischer-Vize, R. Kraut, M. Mlodzik and A. Zitron for comments on the manuscript, and T. Laverty and R. Woodruff for help with stock-keeping. This work was supported in part by postdoctoral fellowships from the Damon Runyon-Walter Winchell Cancer Research Fund (NEB), SERC/NATO (KM) and Helen Hay Whitney Foundation (RWC). Note added in proof in a previous paper (Mlodzik et al., 1990) we referred to the pie gene by another name, rumpled.

Keywords

  • Cell interactions
  • Drosophila eye
  • Genetic screen
  • Pattern formation

ASJC Scopus subject areas

  • Genetics
  • Cellular and Molecular Neuroscience

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